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Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

Discussion in 'Other Health News and Research' started by Mya Symons, May 5, 2013.

  1. Mya Symons

    Mya Symons Mya Symons

    I thought this was an interesting older study that may go hand in hand with this study: Bradley, A. S., Ford, B. and Bansal, A. S. (2013), Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls. Clinical & Experimental Immunology, 172: 73–80. doi: 10.1111/cei.12043


    Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

    • a Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK B15 2TT
    • b Department of Clinical Immunology, Royal Free and University College Medical School, Pond Street, Hampstead, London, UK NW3 2QG
    Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.
    Bob and Enid like this.

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