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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodents

Discussion in 'Other Health News and Research' started by Never Give Up, Aug 13, 2016.

  1. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

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    This seems to have a powerful effect of memory in Alzheimer's patients.

    http://www.nature.com/ncomms/2016/160811/ncomms12504/full/ncomms12504.html

    Is anyone aware of any research related to this in ME patients?
     
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  2. Hutan

    Hutan Senior Member

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    Some background information that might help interpret this:

    There are various classes of NSAIDs (Non-steroidal Anti-inflammatory Drugs):
    http://emedicine.medscape.com/article/2172136-overview
    • Acetic acids
    • COX-2 inhibitors - Celexicob
    • Fenemates - Meclofenamate and Mefenamic acid
    • Oxicam derivatives - eg Meloxicam (Mobic)
    • Propionic acids - eg Fenoprofen and Ibuprofen
    • Salicylates eg Aspirin
    ETA: the article in the OP also mentions Flufenamic acid as one of the fenemates
     
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  3. Hutan

    Hutan Senior Member

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    Meclofenemate doesn't sound great if our mitochondria are already limping along.

    https://edsinfo.wordpress.com/2016/05/07/nsaids-cause-heart-damage/

    (Although, I couldn't see the details of the study. Sounds as though it was on mouse cardiac cells in vitro so perhaps more systemic benefits couldn't be observed.)
     

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