Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data
The Microbe Discovery Project outlines an ambitious new study by top researchers that has collected patient samples, but needs desperately funds to complete the work.
Discuss the article on the Forums.

feeling worse on B12 inj

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by ottiebow, Mar 9, 2012.

  1. ottiebow

    ottiebow

    Messages:
    26
    Likes:
    0
    Hello

    Please can I have some advice, i've been taking 1mil of hydrox...b12 inj once a week with no problem but not really feeling enough benefit so my Dr changed my dose to half a mil every other day. I've been having this for 3 weeks but feeling worse. Not sure if it is the change of dose of B12 or not.

    Can upping the dose of B12 over the week cause you to feel worse in the shortterm while it mops up toxins etc? is this normal?

    thanks
     
  2. baccarat

    baccarat Senior Member

    Messages:
    188
    Likes:
    87
    How much are you taking in mg or mcg (1ml is the volume). What other supplements you're on? are you following the SMP or the active one?
    Worsening of symptoms may be a sign your body is mobilising toxins.
    Rich said that in his study some people took up to eight weeks (I think, not sure the exact length of time) of feeling worse before feeling any better.
     
  3. brenda

    brenda Senior Member

    Messages:
    1,938
    Likes:
    1,467
    UK
    ottiebow

    Are you taking binders like charcoal?
     
  4. therron

    therron

    Messages:
    94
    Likes:
    13
    California
    HI Ottiebow
    Every person is different, but I have found over the past 3 years of trying methylation supplements that I can't handle increasing doses quickly or drastically. Reactions to some supplements are immediate, but the worst reactions don't become evident for about two weeks. I can't really say whether this bad reaction is due to toxins or simply an accumulation of the new supplement due to an ineffecient detox system. For myself, I know that if I get the two week reaction, it will get progressively worse unless I back down on my dose. For many people, this reaction is due to COMT.

    therron
     
  5. Sushi

    Sushi Senior Member Albuquerque

    Messages:
    14,336
    Likes:
    21,486
    Albuquerque
    Yes, knowing the number of mg per ml would help us respond. In my personal experience with injecting hydrox (I inject 3 mg every other day and still need to increase the dose) I've found that I had to titrate the dose up very slowly or I would feel worse.

    Sushi
     
  6. ottiebow

    ottiebow

    Messages:
    26
    Likes:
    0
    sorry for the delay in replying, i've been in bed. I'm taking half a 1mg/1ml of hydroxo. They come in 1mg/1ml ampoule and I keep it in the fridge and have half of this every other day.

    I'm also taking 0.5mil of magnesium per week
    Iron supplement
    vit C
    Vit D 1,000 iu.
    1,000mg Omega 3
    VSL -3 probiotics
    Zinc 15mg
    betaine tablets 2/3 before i eat
    200mg Q10
    Multi vitamin

    I would be really interested to know your thoughts,

    thanks
     
  7. richvank

    richvank Senior Member

    Messages:
    2,716
    Likes:
    876
    Hi, ottiebow.

    That's not a very big dosage of B12 for treating ME/CFS, but as has been noted, some people need to start with a very low dosage and work up. I don't know why you are reacting to it. I think it's possible that you might be reacting to an impurity in the injectable, such as via an allergic reaction. You might try switching to a sublingual form of hydroxocobalamin, such as the HydroxoB12 MegaDrops or the Perque lozenges.

    Does your multi contain a form of folate, such as folic acid or folinic acid, or 5-methyl tetrahydrofolate? For treating ME/CFS, the combination of B12 and folate seems to be the key.
    Folic acid is not such a good form of folate to use, because it takes several reactions to convert it to the forms the body actually uses, and some people are not able to do these conversions very well.

    Best regards,

    Rich
     
  8. ottiebow

    ottiebow

    Messages:
    26
    Likes:
    0
    my mutivit contains 400mg of Folic Acid would this be enough?
     
  9. richvank

    richvank Senior Member

    Messages:
    2,716
    Likes:
    876
    Hi, ottiebow.

    I think it would be a good idea to add some methylfolate (Metafolin, FolaPro, or MethylMate B) and to take it at least two hours away from when you take the multi, so that it will be absorbed well by the gut. Hopefully the folic acid will not interfere with importation of the methylfolate into your cells. In people who do not process folic acid well, it can build up in the blood and hinder the transport of methylfolate into the cells.

    You could also consider changing to a multi that has no folic acid, or one that has methylfolate instead of folic acid, such as the Thorne multis.

    Best regards,

    Rich
     

See more popular forum discussions.

Share This Page