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Feeling terrible after Probiotics

andyguitar

Moderator
Messages
6,610
Location
South east England
Trying to work out which probiotic is useful or harmful would probably take forever:sleep:. But there is credible scientific evidence that show that some can have an effect on serotonin and dopamine levels in the gut and brain. Good or bad? Who can tell? Is taking them worth the risk?
 

JaimeS

Senior Member
Messages
3,408
Location
Silicon Valley, CA
Trying to work out which probiotic is useful or harmful would probably take forever:sleep:. But there is credible scientific evidence that show that some can have an effect on serotonin and dopamine levels in the gut and brain. Good or bad? Who can tell? Is taking them worth the risk?

Was for me; but that was in part because I really needed an antibiotic long-term in order to get to where I am, now; and I needed to re-colonize my gut, somehow. Like all treatments we discuss, there is a good chance that others may not need it; or they may need to re-colonize their gut, but the resultant neuro symptoms could end up making them feel worse overall rather than better. Unfortunately, we have a disease that different people express a little differently.
 

Richard7

Senior Member
Messages
772
Location
Australia
I don't claim to know the answer or rather answers here but:

I do think that when it comes to SIBO the combination of betaine HCL + ox bile + digestive enzymes is a good idea.

The acid issues many pwme/cfs have are pretty well known. The problems we have with bile production and enzyme production seem to be explained by Chris Armstrong's work.

The acid is of course needed to steralise the gut and to provide the right environment (pH 2) for pepsin to break proteins into peptide fragments. Pancreatic enzymes then break these down into amino acids and peptide fragments that are further digested by peptidases at the brush border.

http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/absorb_aacids.html
http://www.vivo.colostate.edu/hbooks/pathphys/digestion/pancreas/exocrine.html

I take creon 25000 (which is a pancreatic extract https://www.nps.org.au/medical-info/medicine-finder/creon-25-000-capsules) which presumably gets me to the brush border but no further and I am a bit concerned about what we do to aid that last stage of digestion if our guts are a mess.

When these things are not working proteins will make ther way into the gut that is dominated by protein digesting bacteria.

The same of couse goes for fats, only I think bile plus pancreatic lipase takes us all the way to the end, and should stop fats from entering the colon in unusually large amounts.

The bile is also good at clearing some bacteria out of the small intestine - though as probiotic bacteria is selected for its resistance to bile it may be the very kind that is most likely to set up residence in the small intestine ... hmmm. Anyway bile can work as a kind of local antibiotic for a lot of bacteria.

So Betaine HCL + oxbile + pancreatic enzymes is a good start for SIBO and issues in the large intestine.

There are still issues with inflamation that can be addressed with Maes's protocol; there are issues with permeability that can be addressed too

and damn I am fading so may have to come back to this, but I think that Ken Lasessen's suggestions re probiotics are pretty good places to start https://cfsremission.com/. But given the issues so many of us seem to have with paracellular permeability I think that it is important to fix that before taking a lot of probiotics.
 

godlovesatrier

Senior Member
Messages
2,554
Location
United Kingdom
Is kefir meant to taste very sour? Or not? I drank some at the weekend and it's fixed my abdominal pains but give me fatigue and very bad brainfog. Could it be a yeast infection I wonder? Haven't got any other signs of that rho not even bad breath.

I've tried almost everything today with very little relief. Andrographis didn't seem to help. I've taken 600mg egcg again not noticed a huge effect.

No idea what I did but it must have unbalanced things. And now it's insanely hard to concentrate.