I've tried to take various methylation related supplements, but I keep having a problem of feeling extremely cold. Is there an explanation for this? The coldness starts in the lower legs, and depending on the dose, makes my whole body frigid for a few hours. Once I took some TMG in the summer, and i had to wear snow pants and my winter coat until it wore off. It's not adrenal stress, and I don't have other symptoms that are serious or noticeable. The supplements that cause it: TMG P5P (also makes my mouth dry until it wears off) folinic acid (never tried methylfolate) Jarrow MB12 What doesn't cause it: lecithin/phosphatidylcholine in large doses does NOT cause it although it's supposed to be a methyl donor folic acid (I guess I don't convert it) AB12 (because it's not a methyl donor? not sure) B6 (obviously a conversion issue) I think it relates to a deficiency in other things, but I need some clues! For example, I have found recently that my liver doesn't produce much bile without P5P, but only on the first day. It seems I need niacinamide and possibly other things for P5P to make my liver work better. However it takes something like weeks of no P5P to replenish the niacinamide and whatever else is needed. I can't tolerate much niacinamide because my liver has a low threshold of toxicity for it. I will be trying NADH and NAD to test this theory further. There are other B vitamin relationships that I have noticed, but I have not been able to crack the cold feeling I get from some of the methylation related supplements. Is there something I've missed??