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Feel better on Prednisone?

Discussion in 'General Treatment' started by Nielk, Jan 15, 2012.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    dosages used for treating anaphylaxis and allergies etc is alot higher then those doses to treat low cortisol levels though. 1-2mg/kg are used for say asthma, where when used for low cortisol doses of 1-2mg total are used. So it doesnt seem the same comparing the 2 levels of dosages. Im thinking more to balance hormones to normal levels??
    August59 likes this.
  2. AFCFS

    AFCFS Senior Member

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    [​IMG]

    (from the site: Adrenal Fatigue and Hormone Therapy)

    Arrgh! - I am wondering if one needs cortisol, if could just take the Pregnenolone? I had one doc tell me to take Pregnenolone and DHEA. On a blood test, Pregnenolone was in range but low, and DHEA was low, mid range.

    Then another doc told me to get off of all supplements that I did not have a direct positive effect from. Some of these type supplemets are works in progress, but I ditched them on that advice. Then another did the ACTH test that was quite low and suggested a visit to an endocrinologist for further evaluation/testing. Further stating that ACTH is a hormone made in the pituitary that stimulates the adrenal gland to make cortisol and that I might benefit from cortisol. The same doc told me not to go back on DHEA b/c in men it may evetually end up as estrogen, which was not a good thing. Roughly described here:
    Per comment by Nielk - I am also very much aware of becoming dependent on meds like Klonopin and would rather not toast my adrenals with some direct input of cortisol if there was a more natural way around it (e.g. Pregnenolone).

    So, am ultimately wondering if the Pregnenolone can cure the cortisol ills without doing long term damage that may be incurred with cortisol direct input?
    August59 likes this.
  3. AFCFS

    AFCFS Senior Member

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    Much more, at the link, but here is an excerpt from the link Adrenal Fatigue and Hormone Therapy:
    So, if one can forgive the author from using the term "Adrenal Fatigue" there is obviously some complexity in here, and not sure exactly how it is to be dealt with. I would not mind having my doc set me up on a dose, but would really not want to have to call them every time I thought I was trending in the wrong direction. Anyone come across the paradoxical reactions and effectively deal with them?

    Not to confuse the issue, but here is another article: Hormone's Benefits Include Enhanced Mental Function, Decreased Cortisol, and Improved Mood

    And then this article, Pregnenolone, with this safety note:
    As well as this: Pregnenolone: Scientific View and Its Outweigh Benefit

    So, while many of its benefits seem appealing, there is a bit of a dark side to it, but, to the topic at hand, am wondering if it is still a better choice than a direct cortisol intake?
  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    good thing about pregnenolone and dhea which is different to other hormones is that there is no negative feedback issues, eg say testosterone, if one took it then the body would stop producing its own testosterone levels, apparently this isnt the case with pregnenolone and dhea.

    Those hormone charts take as a guide as they dont always flow down like that. preg can increase cortisol but not in everyone, really need testing to see where it goes, for some it may increase progesterone or dhea, for some all three. For me it increased cortisol and testosterone but not the other hormones which is strange, especially dhea as u would think it would have to convert to dhea before converting to testosterone, but this didnt seem to be the case.

    When i first started preg i got really over stimulated badly and felt yuk. I always thought it was just increasing cortisol too much. Recently i read something called thyroid dump and this occurrs as when cortisol is increased after being low, it helps the body to use thyroid hormone. I think in those with adrenal fatigue, they say are also hypothyroid(high reverse t3 anyway) but thyroid hormone is still in the blood and tissue floating around not being used until cortisol is increased. When this happens its sort of like having an overdose of thyroid meds initially, where there is increased agitation, sweating, palpitations etc etc so when its said to go low and slow i think its more important when increasing cortisol with preg or hydrocort for this reason. even dhea initially did this to me.

    Over time i have slowly increased dhea and pregnenolone and they have played their part in helping me. progesterone can also help with increasing cortisol too and for some can help with sleep as it can improve gaba receptor sensitivity. Might be helpful for those try to come off benzos too??

    I think its important to have healthy blood levels of hormones but i think in me/cfs we have to do it slowly and in much lower doses then normally recommended. Pregnenolone cream is said to be alot more affective then tablets, dhea i think tabs are said to be better mainly because they are alot cheaper and just as affective. I would recommend using doses of 5mg at a time and slowly increasing in 5mg increments while no adverse symptoms, maybe even using every second day. 50mg of preg and 25mg of dhea is a good dose to aim for, going off blood tests is ideal.

    cheers!!!
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  5. AFCFS

    AFCFS Senior Member

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    Yea, the charts are useful but they also make things look like a nice linear function, which is not the case. After reading more about this, I did find (http://www.lef.org/magazine/mag2004/jun2004_report_preg_01.htm):
    So, maybe in your case, the Pregnenolone is changing into progesterone then cortisol and androstenedione in a snap, then to the testosterone, while bypassing the DHEA - as it is not needed in that given moment? At one point I had a doc that had me on a really high dose of Pregnenolone and DHEA. I can now see the small and gradual ramp-up to make more sense.
    heapsreal likes this.
  6. MishMash

    MishMash *****

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    Plenty of MS patients, particularly middle-aged females, have to take repeated rounds of steroids (I think prednisone is one of them). And some of them have to get knee and hip replacements. There is a problem with bone weakening, breakage. Tread carefully if you take this stuff on a long term basis.
    Kati, Tammy and AFCFS like this.
  7. Tammy

    Tammy Senior Member

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    I would only consider taking steroids like prednisone for an emergency type situation............otherwise I would avoid them at all costs. jmho.
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  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    cortisol steroids we are talking about doses that bring ones levels are to normal not high doses used to decrease inflammation in conditions like arthritis, asthma etc. Theres a big difference between the 2. Having low cortisol levels can have just as many side effects. Its all about balance.
    August59, Ema, AFCFS and 1 other person like this.
  9. PNR2008

    PNR2008 Senior Member

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    If Im understanding you heapsreal, (I never know with this brain fog) then for the emergency situations like bactrim reaction, wasps and yellow jackets stings, and even an inflammation of my spine twice that really scared me, the large doses don't affect me but the tapering off does? It seems odd but intervenous steriods feel like nothing but probably save my life. Yet taking the tapering pills sends me in orbit. My mom had RA and needed pred to function, my cousin has transverse mylitis and needs pred for relapses, she says it feel wonderful to have no pain, another aunt had addison's and took pred everyday. I feel terrible whatever I take. Weird.
  10. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I think thats one of the mystery of cfs/me, what helps one can make another feel awful. Also what makes u feel bad one time and as ones physiology changes with this illness that same treatment can do the reverse. treatment is all about educated guess, trial and error.

    Different things i have tried for adrenals have made me feel terrible, mainly when my adrenals were really low which was noted on testing dhea/cortisol, apparently adverse reactions are more common when adrenals are really low. But since i have slowly improved my adrenal function with dhea/pregnenolone the adverse reactions have reduced. one eg is i use to be able to tolerate siberian ginseng earlier in my cfs/me, about 2 yrs ago when testing showed my adrenals trashed, i tried ginseng just 1 pill and it over stimulated me and i felt terrible. The other day out of curiosity i took the same brand of sib ginseng and had no issues at all. Dr lams web site on adrenal fatigue mentions this. SO i think many of us have adrenal issues but we have to be very careful how we go about treating it as we are more prone to these adverse reactions. If pregnenolone overstimulated u then maybe try ultra low doses and build up slowly or try another method, maybe ultra low doses of dhea or herbals. I think its very tricky and individual and a bad reaction can be scary thing too. Its hard to find a good doc to work with this stuff too.

    Adrenals also are only part of our problem, sometimes fixing them doesnt improve us until we get other issues sorted like an infection etc. its a piece of the puzzle??
    August59 likes this.
  11. YvieArtist

    YvieArtist Artist and survivor.

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    Hello all. I have been to an endo doctor and scheduled for a ACTH test on Wednesday for the cortisol levels. I have been getting worse and mostly on my sofa now and can't do much at all. Shower knocks me out, I can make my bed and get pizza out of freezer to eat at least. Some family members help me shop for groceries and wash. Live alone and this is the pits! When I was on Prednisone almost all of my symptoms went away back in June, but other doctor did not want me on it for long. My new lab tests did show low cortisol levels so new endo doc wants this test done. Hopefully I get treated for this low cortisol. I'm hoping to get some of my life back. (Had this bad relapse for two years now) Had ten good years prior to this relapse which happened as to overwork trying to support myself. Now on SS retirement, thank God!
    heapsreal likes this.
  12. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Of late my pregnenolone cream i have noticed doesnt seem to be as affective as it once did, but i have been using the same jar of preg cream for 2 yrs now, lasted so long as i didnt use as much. The compounding pharmacy put a 3 month expiration date on it but i found it still working even after 12 months or more. I have a new jar that i havent used yet but today i thought i would try it, wow! i now know my old cream had definately expired because the new cream is working well. old jar is in the bin. This might be why i have been tolerating higher and higher doses of pregnenolone. Definately more energy, maybe better cortisol levels??

    lesson learnt, keep eye on expiration date of preg cream, if older then 12 months then bin it??

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