Here is my methylation data: https://drive.google.com/open?id=0By9VwoUlJRdCWmZ6Sl82cWJ4R2c I decided to try a quality B-Complex: https://numedica.com/Product_detail.cfm?Fname=NM150 Yesterday which happened to be the 3rd day, I felt very irritable, anxious, wired and generally restless. Upon investigation it seems that a lot of people experience side effects with methylfolate and/or methylB12 if the dose is too high. My B-complex seems reasonably dosed except that it also has 400mcg of folinic acid on top of 400mcg of methylfolate - could that be causing my issues? I'm heterogyzous for most MTHFR and COMT genes so I should do well with some methylB12 and methylfolate in theory, not sure why I'm having these issues. Perhaps I could try lowering the dose? It looks like most b-complexes on the market have 400mcg of methylfolate so I would have to take half a capsule. For what it's worth, I don't have the same symptoms today as I did yesterday but I did take uridine (UMP) which supposedly eats up folate. Also, I took TMG for over a year and I remember being very irritable during that period of time but never made the connection.