From the IACFSME Here are some references about the drug, taken from Broken Marionette Duschek S, Hadjamu M, Schandry R. Enhancement of cerebral blood flow and cognitive performance following pharmacological blood pressure elevation in chronic hypotension. Psychophysiology. 2007 Jan;44 (1):145–53. AACFS conference January 2001. Report by Dr. Rosamund Vallings. http://www.cfs-news.org/aacfs-01.htm Naschitz J, Dreyfuss D, Yeshurun D, et al. Midodrine treatment for chronic fatigue syndrome. Postgrad Med J. 2004 Apr;80(942):230–2. Naschitz JE, Rosner I, Rozenbaum M, et al. Successful treatment of chronic fatigue syndrome with midodrine: a pilot study. Clin Exp Rheumatol. 2003 May–Jun;21(3):416–7. Goldstein Jay. Tuning the Brain: Principles and Practice of Neurosomatic Medicine. Haworth Press 2004. p. 93.