This study is fascinating because it ties depression to evolution. Depression could be a way to adapt and survive infections. Interesting is also the outcome. The scientists say that people with depression have higher inflammation markers although they don't seem to be infected. This raises the question if inflammation alone can also lead to depression. However, their statement is not easy to prove in my eyes. How do they test for infections? There are probably thousands of different infections and I highly doubt that we have the diagnostic means to test for all of them. In the end however it's still very interesting that depression can be absolutely independent from psychological factors. Depression can be a pure physical disease and nothing else. It's time that psychologist accept this and stop using all kinds of crazy, unscientific and wrong explanations for their patients' burden. So if a person stayed away from other people because he was depressed, this reduced his risk of getting infected by these other humans if they were ill. Fascinating. http://www.sciencedaily.com/releases/2012/03/120301103756.htm Depression: An Evolutionary Byproduct of Immune System? ScienceDaily (Mar. 1, 2012) Depression is common enough -- afflicting one in ten adults in the United States -- that it seems the possibility of depression must be "hard-wired" into our brains. This has led biologists to propose several theories to account for how depression, or behaviors linked to it, can somehow offer an evolutionary advantage. Some previous proposals for the role of depression in evolution have focused on how it affects behavior in a social context. A pair of psychiatrists addresses this puzzle in a different way, tying together depression and resistance to infection. They propose that genetic variations that promote depression arose during evolution because they helped our ancestors fight infection. An outline of their proposal appears online in the journal Molecular Psychiatry. The co-authors are Andrew Miller, MD, William P. Timmie professor of psychiatry and behavioral sciences at Emory and director of psychiatric oncology at Winship Cancer Institute, and Charles Raison, MD, previously at Emory and now at the University of Arizona. For several years, researchers have seen links between depression and inflammation, or over-activation of the immune system. People with depression tend to have higher levels of inflammation, even if they're not fighting an infection. "Most of the genetic variations that have been linked to depression turn out to affect the function of the immune system," Miller says. "This led us to rethink why depression seems to stay embedded in the genome." "The basic idea is that depression and the genes that promote it were very adaptive for helping people -- especially young children -- not die of infection in the ancestral environment, even if those same behaviors are not helpful in our relationships with other people," Raison says. Infection was the major cause of death in humans' early history, so surviving infection was a key determinant in whether someone was able to pass on his or her genes. The authors propose that evolution and genetics have bound together depressive symptoms and physiological responses that were selected on the basis of reducing mortality from infection. Fever, fatigue/inactivity, social avoidance and anorexia can all be seen as adaptive behaviors in light of the need to contain infection, they write. The theory provides a new explanation for why stress is a risk factor for depression. The link between stress and depression can be seen as the byproduct of a process that preactivates the immune system in anticipation of a wound, they write. Similarly, a disruption of sleep patterns can be seen in both mood disorders and when the immune system is activated. This may come from our ancestors' need to stay on alert to fend off predators after injury, Miller says. Miller and Raison's theory could also guide future research on depression. In particular, the presence of biomarkers for inflammation may be able to predict whether someone will respond to various treatments for depression. Miller and Raison are involved in ongoing research on whether certain medications, which are normally used to treat auto-immune diseases, can be effective with treatment-resistant depression.