I fell very ill in January this year and over the first months of intense downward spiral of all the symptoms and things happening one of the most major is a serious tissue wasting/atrophy that occurred over every square cm of my body that took a few months to progress. I saw there was another thread on muscle wasting, and I thought I would add to that but I know this is much more than muscle because every part of my body, even all the places which anatomically do not have any muscle lost tissue. I am certain of this. Even my friends and family noticed that all these veins have become exposed everywhere on my body that weren't before and my skin has gotten very very soft and flabby. My face and eyes look so tired because of this :-( It started probably right when I got sick it's just I didn't notice, yet maybe a month or so into the disease I was getting severe numbness/tingling and pain in my extremities and my socks started leaving huge indentations in my legs and feet that they never did before and it wasn't edema/swelling. My underwear would also leave marks when it didn't before. I am a thin and muscular person and never had any indentations left by clothes. The period of rapid wasting seemed to slow down or stabilize a couple months ago and coinciding with that the daily numbness/tingling and pain went away, they definitely were connected. This isn't due to inactivity because even though I cannot exercise anymore I still work and am able to get around and have not stayed in bed. It was just too rapid and it is definitely because of the disease causing something to go horribly wrong. Does anyone have any thoughts as to the root cause of this? Based on how I feel my disease is progressing if I can correct what caused this it would fix a lot of my problems. I am already doing all the mitochondrial dysfunction, methylation/folate cycle, glutathione protocols and taking supplements to counteract possible hypercoagulation.