1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Leptin
Andrew Gladman reflects upon the recent IACFS/ME conference and the buzz surrounding a small molecule, leptin.
Discuss the article on the Forums.

Faecal transplant eases symptoms of Parkinson's (and CFS)

Discussion in 'Latest ME/CFS Research' started by Bob, Jan 26, 2011.

  1. Bob

    Bob

    Messages:
    7,435
    Likes:
    8,577
    England, UK
    Hi RunningOnEmpty!
    A very big welcome to the forum to you!
    I hope you have a happy time here.
    Best wishes,
    Bob
  2. Bob

    Bob

    Messages:
    7,435
    Likes:
    8,577
    England, UK

    I've no idea where you could find a doctor to help with this, but it might be worth contacting the researcher referred to in the article posted at the beginning of this thread...

    The researcher is Prof Thomas Borody, a gastroenterologist at the Centre for Digestive Diseases in New South Wales, Australia...

    Here is his profile page, and the contact details for the Centre for Digestive Diseases, in New South Wales, are at the top right-hand corner of his profile page...
    http://www.cdd.com.au/pages/clinical_staff.html
  3. RunningOnEmpty

    RunningOnEmpty

    Messages:
    2
    Likes:
    1
    Thanks Bob!! I will contact Dr Borody.

    Best regards,
    D.
  4. pinkytuscadaro

    pinkytuscadaro

    Messages:
    68
    Likes:
    3
    Seattle Washington
    Dainty,
    I am considering it for sure.
    Please Dainty keep me up to date on your research.
    If the RV's don't work out for me this may be my next trial.
    We never know what tomorrow may bring :)
    Pinky
  5. Glynis Steele

    Glynis Steele Senior Member

    Messages:
    400
    Likes:
    82
    Newcastle upon Tyne UK
    jenbooks said
    Hi Jenbooks and Dainty,

    I found this study which seems to suggest that prior abx treatment might not be needed, or at least I think this is what it is saying?...

    Reshaping the gut microbiome with bacterial transplantation and antibiotic intake
    Chaysavanh Manichanh1,5, Jens Reeder2, Prudence Gibert1, Encarna Varela1, Marta Llopis1, Maria Antolin1, Roderic Guigo3, Rob Knight2,4 and Francisco Guarner1
    + Author Affiliations

    1 Digestive System Research Unit, University Hospital Vall d'Hebron, Ciberehd, 08035 Barcelona, Spain;
    2 Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA;
    3 Center for Genomic Regulation, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain;
    4 Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
    Abstract
    The intestinal microbiota consists of over 1000 species, which play key roles in gut physiology and homeostasis. Imbalances in the composition of this bacterial community can lead to transient intestinal dysfunctions and chronic disease states. Understanding how to manipulate this ecosystem is thus essential for treating many disorders. In this study, we took advantage of recently developed tools for deep sequencing and phylogenetic clustering to examine the long-term effects of exogenous microbiota transplantation combined with and without an antibiotic pretreatment. In our rat model, deep sequencing revealed an intestinal bacterial diversity exceeding that of the human gut by a factor of two to three. The transplantation produced a marked increase in the microbial diversity of the recipients, which stemmed from both capture of new phylotypes and increase in abundance of others. However, when transplantation was performed after antibiotic intake, the resulting state simply combined the reshaping effects of the individual treatments (including the reduced diversity from antibiotic treatment alone). Therefore, lowering the recipient bacterial load by antibiotic intake prior to transplantation did not increase establishment of the donor phylotypes, although some dominant lineages still transferred successfully. Remarkably, all of these effects were observed after 1 mo of treatment and persisted after 3 mo. Overall, our results indicate that the indigenous gut microbial composition is more plastic that previously anticipated. However, since antibiotic pretreatment counterintuitively interferes with the establishment of an exogenous community, such plasticity is likely conditioned more by the altered microbiome gut homeostasis caused by antibiotics than by the primary bacterial loss

    Glynis
  6. Nielk

    Nielk

    Messages:
    5,073
    Likes:
    4,603
    Queens, NY
    I have been very perplexed by this thread.
    We are constantly told to DETOXIFY our bodies. clean out our system, take probiotics, take digestive enzymes, take colonics to clean out your intestines.

    Now it seems that introducing foreign exposures into our body, will heal us?
    If we can't fight our own toxicity, how will we fight off someone elses?
  7. jenbooks

    jenbooks Guest

    Messages:
    1,220
    Likes:
    112
    You're getting a fecal transplant from a healthy person, Neil, with a robust and thriving, balanced flora that will help correct the imbalances in your own.
  8. Nielk

    Nielk

    Messages:
    5,073
    Likes:
    4,603
    Queens, NY
    #1- why not just get rid of our problematic fecal wastes that reside in our bodies with a series of colonics.

    #2- if a transplant is needed to balance our flora, how long would this stay in our system? doesn't it get eliminated?
  9. Bob

    Bob

    Messages:
    7,435
    Likes:
    8,577
    England, UK
    Good questions, Nielk...
    I'm not an expert in this subject, but my understanding is as follows...
    The purpose of a faecal transplant, is purely to introduce healthy colon bacteria into our colons/gut...
    This is very similar to taking probiotics, except that the bacteria will be naturally occurring, and obviously the method is very different.
    Once the feaces has been implanted, then the beneficial bacteria in it will take residence in your own colon, and start to feed on your own waste.
    The implanted feacal matter will soon be expelled (i.e you will go to toilet), leaving the healthy bacteria behind, residing and thriving in your own colon.
    I think that's the theory behind it, anyway.
  10. Bob

    Bob

    Messages:
    7,435
    Likes:
    8,577
    England, UK
    aimossy likes this.
  11. Bob

    Bob

    Messages:
    7,435
    Likes:
    8,577
    England, UK
    BBC Radio 4: "Case Notes" - Gut Bacteria

    A program about our favourite subject - "Faecal Transplants"

    http://www.bbc.co.uk/programmes/b00z6dvv

    It should be on BBC iplayer for UK residents for 7 days.

    I've only listened to a bit of it so far... it sounds interesting.
  12. Jenny

    Jenny Senior Member

    Messages:
    1,223
    Likes:
    172
    London
    Thanks Bob - this is an interesting programme. Talks about probiotics and prebiotics too.

    It's already available on iplayer.

    Jenny
  13. redo

    redo Senior Member

    Messages:
    830
    Likes:
    89
    Thank you very much for that info. I hadn't heard about IgA's role in this. Nor the hypothesis that the viruses may interfere with the body's ability to regulate the gut properly.

    I got worse after a food poisoning. It was at the very beginning of my disease.
    aimossy likes this.
  14. Glynis Steele

    Glynis Steele Senior Member

    Messages:
    400
    Likes:
    82
    Newcastle upon Tyne UK
    aimossy likes this.
  15. redo

    redo Senior Member

    Messages:
    830
    Likes:
    89
    @Glynis. Thanks.

    It's been about a month since you posted. Please let us know how's it going. I'd love to hear it if youmve begun some test treatment.

    I guess too that although nothing is without risk, this is a lot less risky than many other treatments.
  16. redo

    redo Senior Member

    Messages:
    830
    Likes:
    89
    "But its not like they put it on a plate and have you eat it. You dont ever see or smell a thing.
    "People will have a blood transplant or a kidney transplant whats the difference with this?"

    Here is the procedure:
    They insert a tube down to the gut (you don't even get to see anything). It's no worse than other treatments. Please don't make this into a joke thread. On a case basis it has worked for CFS, RA and MS. That is really great. The fact that it works in these conditions which I have for long suspected have a common nominator (such as clostridum bacteria or other microbes in the gut) makes the case reports more valid to me.

    http://qjmed.oxfordjournals.org/content/102/11/781.full

    Excerpt from the NewScientist artice:
    Over the past decade, Borody has noticed that some of his patients also see improvements in symptoms of their other diseases, including Parkinson's, multiple sclerosis (MS), chronic fatigue syndrome (CFS) and rheumatoid arthritis. "Some CFS patients, given a faecal transplant, will regain their energy quite dramatically, and their foggy brains will get better," says Borody. (my bold)

    If I lived in the UK, I would defiantly try this. The scientists who published the study showing it could cure 11 out of 15 people with c. difficile are from the UK.
  17. redo

    redo Senior Member

    Messages:
    830
    Likes:
    89
    If we were suffering from headaches or influenza I might laugh at people trying to change the content of their intestines. But when it's a disease which has totally destroyed everything for me, it's a totally different story. Please let's make this thread about the treatment, it's effects, and why it might/might not work.
  18. redo

    redo Senior Member

    Messages:
    830
    Likes:
    89
    It seems to work very well for C. difficile:

    More than 90 per cent of C. difficile patients are cured by fecal transplants, studies suggest

    And: Fecal transplants have become the first-line treatment for chronic recurrent C. difficile in Scandinavia. As well, more and more doctors are using it in the United States.

    Calgary physician Dr. Tom Louie, head of infection control at Foothills Hospital, is one of the few physicians in Canada who treats patients with chronic C. difficile with fecal transplants, or fecal therapy. He has done 38 procedures to date.

    Another doctor from Canada has published a study about it.

    The quotes above are from this article:
    http://www.cbc.ca/news/health/story/2007/11/13/fecal-transplant.html

    Point is: Although not very common, it's a procedure which seems to be at use in various countries.

    My guess is that this is more harmless than many other experimental CFS treatments.

    The procedure is being used many places, for Clostridum infections.
  19. Enid

    Enid Senior Member

    Messages:
    3,309
    Likes:
    838
    UK
    Much enjoying the humour here but with such a list - Parkinsons,MS,Rheum Arth, Diabetes,CFS,Autoimmunities - it's pretty obvious the correct functioning of the gut is far more important/fundamental with wider disease processes than was previously realised. Major organ.
  20. mingo

    mingo

    Messages:
    5
    Likes:
    1
    aimossy likes this.

See more popular forum discussions.

Share This Page