I know Freddd says that much of what we ascribe to detox is actually either a Folate or a Potassium deficiency. My eyes have long been dry and scratchy at night and occasionally red-rimmed and weepy during the day, and react with mostly lid puffiness to many things from Tylenol to mineral supps that cause a lot of detox for me, like selenium, and even zinc, which I’ve been increasing. With the introduction of methylation they seem to have gotten worse. For a little over a month I've increased my MeB12 , along with the Folate, in a roughly 2:1 ratio currently (500mcg MeB12: 200mcg Folate). Yesterday, I upped the dose to 1,000mcg MeB12 and 400mcg Folate and, while I expected worse sleep, I also woke with much puffier eyes this morning. I’ve used a rinse at night to alleviate this symptom—each time I get up to pee, which is every couple of hours (believe it or not, my sleep is better on the methyls!)—but now, some of that stickiness is creeping into my day. (I feel like whack-a-mole with all these symptoms?! ) I’ve made an appointment to see the opthamologist next week, but any of you who’ve made progress on methylation know I don’t really want to backtrack—every time I do my pain is worse. In case this plays into it at all, I’m now taking Nature Made B-complex, which has very low Bs: Vitamin C 300 mg Thiamin 15 mg Riboflavin 10.2 mg Niacin 50 mg Vitamin B6 5 mg (plus an additional 25 mg p5p from pure encapsulations) Pantothenic Acid 10 mg Could these eye issues relate to my detoxification pathways and possibly not doing enough work on them prior to starting the methyls? Any thoughts?