My wife, whom I written about before on this forum, suffers frm an extreme form of ME/CFS. Her condition has deteriorated as well during September-October. SHe now suffers from en extreme form of PEM where her muscles just wont work. A little bit to much work for the muscles (and in her case that can be putting som pills into her mouth) and it jsut says stop. She descibes it as when your lifting weights at the gym and after a number of repeats your muscles just will not be able to lift the weight anymore. I don't know if this is a lactic acid thing or has to do with enery levels. Any experiences from anyone?