I had to detox high heavy metals (copper was one of them too high) a year ago, then again a few months ago. And as you will read, there will be fatigue involved. But my fatigue was ten ton fatigue--much more debilitating than I've heard of anyone having from detoxing. Now yes, I do have a mitochondrial problem, but I seem to be fine when I'm not detoxing with the right supplements, which include pqq, high dose coq10 ubiquinol, l-carnitine and a few others. i.e. I have what feels like the right amount of energy. But as soon as I start to detox....it's like I fall down a deep, dark crack in the earth to some of the worst kind of fatigue one can imagine. It hinders my abilities to do anything. And I'd like to know why!!! 1) DETOX GENES: I first wondered if I have mutations that make me detox far too aggressively, like an up-regulation detox issue. The only ++ homozygous showing is CTH rs1021737, which shows a higher risk for high homocysteine, but mine isn't high at all. There are four +- heterozygous in the CYP's, but all show "ambiguous" results. I also have two NAT2 hetero's, but nothing I see fits having a too aggressive detox gene. 2) MITOCHONDRIAL: I then moved to my mitochondria issues, asking myself: Do I just not have a good enough mito function to respond well to a detox? I have wondered about that. But the second time I detoxed with that kind of fatigue, I had been supplementing for my mito very well, yet still the same massive fatigue. 3) METHYLATION: I do have several mutations that can be effecting methylation. Even though I'm only hetero for MTHFR 1298, I have several issues with both mao-a and moa-b, COMT, mtrr and others. But I had been treating them, and still the debilitating fatigue with detox. Would being a high adrenaline person cause detoxing to wipe me out? I don't know. I wish I did. Anyway, that's the question and if you have any ideas why someone would have this kind of massive, debilitating fatigue with detoxing....much more than I've seen anyone else describe, I'd love ideas to explore! P.S. Forgot to add--I did try taking extra niacin and potassium to see if that would help the extreme fatigue, but only tried two days and didn't see any change. Maybe try longer??