I recently started transdermal LDN. I have problems with pain, sleep, and immunity, so I wanted to try it. Although the transdermal form is not as well absorbed or well studied as the oral form, my doctor often prescribes it for his super-sensitive patients who also have digestive issues. 1 MG. I started at this dose and had these effects: Helped sleep from beginning although it was still broken Some back-and-neck pain relief, about 20%. More dream recall. A couple of zits (most undignified at my age!) and increased sweating. Some IBS symptoms. This is a condition I've had in the past, but got well under control with diet and supplements. I was puzzled that the transdermal form could cause IBS symptoms since it bypasses the digestive tract. Strong feeling of surrealism and depersonalization although I still felt myself in my body. This is a different feeling from my usual brain fog and sleep deprivation. On day 5 or 6, for several hours in the late afternoon I had a sudden feeling of much better cognitive function.That never happpened again. So the pain relief and better sleep was great, and I was very hopeful. However, after a week, the LDN seemed to stop working for me. I did find out that you are supposed to rotate sites of application with transdermal LDN. Well, I didn't know that and had been applying it to just one place. However, rotating sites only helped a little bit, so I asked my nurse practitioner if I could increase the dose to 2 MG, and she agreed. 2 MG My sleep got even better at this dosage. Degree of pain relief stayed the same. Experienced more of the dream-like waking state and the feeling of unreality. I stayed on this dose about a week, but, again, it seemed to stop working, and I was back to the same amount of pain and the same pre-LDN sleep problems. So I decided to try 3 MG since my nurse practitioner had told me many of their patients seem to do best at this dose, and I could experiment to find the best dose. 3 MG No improvement in sleep or pain. Much more feeling of unreality during the day. I've just gone back down to 2 MG now, thinking maybe I titrated up too quickly. I may have hosed myself by starting to take a lot of Lauricidin when I during the time I was first taking 2 MG of the transdermal LDN. I have chronic sinus infections, and 2 types of fungus have cultured in the past several months. My ENT has me using Itraconazole in my Sinugator twice a day. She also suggested oral Diflucan for further support (1 tablet a day for three days and 1 tablet a week thereafter), but I haven't wanted to do that since Diflucan has give me really bad insomnia in the past. So I decided to try Lauricidin 3 X daily. I think that may have had the same kind of insomnia effect that oral Diflucan had for me in the past. So I stopped taking it yesterday, and I did sleep a little better last night. I think I've read that if you have any fungus you shouldn't take LDN. However, I never seem to get over my sinus infections, so that would mean I could never take LDN. I want to take it because I had such good initial results. I may not have systemic fungus because I'm not having any vaginal symptoms. I'm hoping the fungus is confined to my sinuses. Sorry I've gone on so long about this. The upshot is that I'm going to stay at 2 MG of the transdermal for awhile and see if the LDN will help again now that I'm off Lauricidin (if that had anything to do with the LDN stopping working). If that doesn't help, I'll try the lowest dose of the oral form. Any thoughts? Thanks.