Has any of you ever tried exogenous ketones as a supplement? I have found low level of ketones (both acetoacetate and 3-hydroxybutyrate) in urines from three patients (I am one of them). If cells (including brain cells) can't burn glucose properly (as the last study by Fluge & co. has suggested) then ketones could represent a valuable source of energy, expecially for the brain, which can't oxidise fatty acids. I have seen that Maureen Hanson measured acetoacetate in blood in her study (row data here) and that there is a slight increase in the level of this metabolite in patients compared to controls which is not statistically significant (diagram below). Could there be an increase in use of ketones in ME/CFS patients with a consequent low urinary excretion? Might ketones be useful as a therapy?