Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Exogenous Ketones

Discussion in 'General Treatment' started by paolo, Jul 28, 2017.

  1. paolo

    paolo Senior Member

    Messages:
    192
    Likes:
    530
    Italy
    Has any of you ever tried exogenous ketones as a supplement? I have found low level of ketones (both acetoacetate and 3-hydroxybutyrate) in urines from three patients (I am one of them).

    If cells (including brain cells) can't burn glucose properly (as the last study by Fluge & co. has suggested) then ketones could represent a valuable source of energy, expecially for the brain, which can't oxidise fatty acids.

    I have seen that Maureen Hanson measured acetoacetate in blood in her study (row data here) and that there is a slight increase in the level of this metabolite in patients compared to controls which is not statistically significant (diagram below).

    Could there be an increase in use of ketones in ME/CFS patients with a consequent low urinary excretion? Might ketones be useful as a therapy?

    upload_2017-7-28_18-3-17.png
     
    Last edited: Aug 3, 2017
  2. cb2

    cb2 Senior Member

    Messages:
    269
    Likes:
    86
    Would you have to be following a ketogenic diet for the exogenous keytone to work?
    Thanks
     
  3. paolo

    paolo Senior Member

    Messages:
    192
    Likes:
    530
    Italy
    No, you have just to eat them, with no changes in your diet. This is the idea. A ketogenic diet induces the production of ketones by the liver, but you can also eat them. You can read this study on the use of ketones as a supplement.
     
    Last edited: Jul 28, 2017
  4. Basilico

    Basilico Florida

    Messages:
    819
    Likes:
    1,943
    My husband wrote a huge post on his experiment with taking Ketones here:
    http://forums.phoenixrising.me/inde...sed-activity-tolerance-and-reduced-pem.52639/

    He didn't write about this in his post (I'll send him a reminder to add it in a follow-up post) but he did find that there was a huge difference in how effective the Ketones were depending on his diet. They need to be taken with a high fat/no carb (keto) diet. Taking them with carbohydrates completely cancelled them out, so there was no benefit at all. He also found that they need to be taken on an empty stomach because taking them with a meal reduced efficacy (unclear why that would happen). The ketones also had the opposite effect on his blood glucose and insulin sensitivity as would be expected (which goes against everything we've read).
     
    Last edited: Jul 28, 2017
    paolo likes this.
  5. paolo

    paolo Senior Member

    Messages:
    192
    Likes:
    530
    Italy
    I searched for posts on this topic but I missed this one. Thank you!
     
    Basilico likes this.

See more popular forum discussions.

Share This Page