Hi all, I suffered a big relapse 2 years ago after I did some yoga. I know that exercise induced relapses are common in people with ME, made worse by GET for example. I've not been able to find any references or discussion on how exercise could be causing these relapses and what could potentially be going on biologically. I'm interested in anybody's thoughts or if there have been any other discussion I've missed on here. Here is my own personal view which is obviously pure speculation (it's difficult not to when you are in this position): Autoimmunity seems to be a popular theory for the disease mechanism of at least a subset of ME patients e.g. Rituximab. It doesn't seem to be much of a jump to think that an exercise induce relapse could be an autoimmune response to some component of exercise. Im also interested in the treatment implications, For example Could people who have had an exercise induced relapse be potential responders to Rituximab? I did have some benefit from LDN but was unable to tolerate due to side effects. Any thoughts would be most welcome.