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Exercise Alters Epigenetics

Discussion in 'Other Health News and Research' started by charityfundraiser, Mar 7, 2012.

  1. charityfundraiser

    charityfundraiser Senior Member

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    Interesting since we were just discussing the effect of high-intensity exercise on insulin sensitivity (in healthy people). Also interesting since epigenetics may have gotten us into CFS.

    Exercise Alters Epigenetics
    Exercise causes short-term changes in DNA methylation and gene expression in muscle tissue that may have implications for type 2 diabetes.
    http://the-scientist.com/2012/03/06/exercise-alters-epigenetics/

    "Exercise can delay the onset of diabetes by boosting the expression of genes involved in muscle oxidation and glucose regulation. A new study, published today (March 6) in Cell Metabolism, suggests that DNA methylation drives some of these changes, and that they can occur within just a few hours of exercise, providing a potential mechanism for how exercise protects the body from metabolic disease."
    LilacGardenia likes this.
  2. ramakentesh

    ramakentesh Senior Member

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    Great post thanks. i once talked to a guy that worked in medical research in epigenetics. An interesting area and it has been implicated in many 'acquired' illnesses including POTS.

    He was saying how they demonstrated that high exposure to glucose in the first four years of life effected epigenetic hypermethylation and promoter downregulation of certain genes later in life. So not only could there be triggers during the time of the onset of an acquired epigenetic illness but perhaps several decades before.
  3. Astrocyte

    Astrocyte

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    Thanks for posting charityfundraiser. Fascinating that epigentics, which were once thought fixed, have now been shown to be dynamic as suggested in this article. That leaves room for intervention! And ramakentesh, I think that prior high levels of intensive exercise decades earlier are possibly associated with later abnormalities in certain systems. Take a look at the HSP thread. All seems a bit harsh if you ask me.
  4. redo

    redo Senior Member

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    That's some fascinating research charityfundraiser. For those new to the whole epigenetics/endogenous retrovirus realm, I'd recommend this:
    www.ncbi.nlm.nih.gov/m/pubmed/19697163/
    It's about the MS retrovirus (which is something we're born with, latently, and may activate when the conditions are "right" -- retroviruses we're born with are called "endogenous" retroviruses). It's epigenetic control which silences these retroviruses. DNA methylation is key to switching on and off epigenetic changes, thereby also silencing active endogenous retroviruses (IMO this is really interesting in the light of Richvank's work, showing many PWME benefits from going an a methylation protocol).

    I made a thread about this, called something like "RNA viruses and methylation", with many relevant abstracts in it. The exercising/ epigentic changes mechanism also fit very well into the GIRA theory (I know, I should have put in more of the train of thought and sources, I'll get back to that later).

    The MS retrovirus is actually an endogenous gammaretrovirus, and incidently the virus Lipkin et al is on the hunt for now are gammaretroviruses, and they are very open to the possibility that it may be endogenous.
  5. Cort

    Cort Phoenix Rising Founder

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    Do you know if that's the study that was referred to at the CAA webinar by Suzanne Vernon which showed epigenetic changes can occur very rapidly? '

    Do you know where that thread is Redo?
  6. justy

    justy Senior Member

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    I just want to know how to alter them back! this is such a fascinating and useful field for us, but as exercise of any sort is out of the window for us, im not sure what we need to do.
  7. rydra_wong

    rydra_wong Guest

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    I understand that we can affect if methyls are added or subtracted from genes...but what does it mean to 'alter the genome'? You can't permanently add or subtract methyls can you? Does it mean we can somehow fix our genetic defects?

    Too bad this doesnt help me -- I have low blood sugar issues. I think exercise lowers it more. Although I can't recall that exercise actually did that to me...but certain supplements can do it to me big time, and hypothyroid does it to me too. And allergy attacks. And sometimes the cause is unknown...

    Rydra
  8. redo

    redo Senior Member

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  9. lizw118

    lizw118 Senior Member

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  10. topaz

    topaz Senior Member

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    Thanks for the youtube link.

    Six degrees of separation alive and well on the internet. Several weeks ago on an Amy Yasko video, she mentioned the mice study in terms of epigenetics and just today I chanced upon this info about receipts and BPA (BPA and ink mentioned at around 46:22min on the youtube vid you posted) http://www.thehealthyhomeeconomist.com/toxic-money-how-to-protect-yourself/

    Interesting.

    I enjoyed the vid you posted as it connected a lot of issues Id come across seperately.

    Thanks

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