Interesting since we were just discussing the effect of high-intensity exercise on insulin sensitivity (in healthy people). Also interesting since epigenetics may have gotten us into CFS. Exercise Alters Epigenetics Exercise causes short-term changes in DNA methylation and gene expression in muscle tissue that may have implications for type 2 diabetes. http://the-scientist.com/2012/03/06/exercise-alters-epigenetics/ "Exercise can delay the onset of diabetes by boosting the expression of genes involved in muscle oxidation and glucose regulation. A new study, published today (March 6) in Cell Metabolism, suggests that DNA methylation drives some of these changes, and that they can occur within just a few hours of exercise, providing a potential mechanism for how exercise protects the body from metabolic disease."