Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
Discuss the article on the Forums.

Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lac

Discussion in 'Latest ME/CFS Research' started by Never Give Up, Jun 8, 2017.

  1. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    970
    Likes:
    4,014
  2. AndyPR

    AndyPR Senior Member

    A bit more detail. The paper is open access.

     
  3. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Messages:
    7,998
    Likes:
    12,914
    Cornwall, UK
    There's a huge range of articles here about d-lactate/d-lactic acid - you'll find them if you search for 'lactate'.
     
  4. SB_1108

    SB_1108 Senior Member

    Messages:
    315
    Likes:
    767
    Can we all start requesting lactate testing when we feel like we are in lactic acidosis? How would be the best way to measure? Anion gap? There are lactic acid meters. Would that work?
     
  5. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,887
    A clinical blood gas analysis would include info regarding anion gap, and give more information about the type of acidosis (or alkalosis).

    Yes, but only for testing lactate levels. They don't indicate if there's acidosis or not.
     
  6. RogerBlack

    RogerBlack Senior Member

    Messages:
    897
    Likes:
    2,903
    https://www.ncbi.nlm.nih.gov/pubmed/28320179 "The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH)."

    https://www.ncbi.nlm.nih.gov/pubmed/22281935 "We found elevated ventricular lactate and decreased GSH in patients with CFS and MDD relative to HVs."

    As I read the various papers, several seem to have taken possibly meaningful measures of lactate, for monitoring 'subclinical' effects.
     
    ljimbo423 likes this.
  7. msf

    msf Senior Member

    Messages:
    3,294
    Likes:
    4,616
    When I saw this article I thought about the similar KDM article about 4 years ago, and then I thought about my father (who also had ME) talking about the lactic acid problems he had when I was maybe 10 years old (20 years ago, and he might have identified it as a lactic acid problem 15 years before that). Science sure moves slowly sometimes.
     
    SB_1108 and Helen like this.

See more popular forum discussions.

Share This Page