Evidence for the existence of ME/CFS with & without abdominal discomfort (irritable bowel) syndrome

Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome.
Maes M, Leunis JC, Geffard M, Berk M.
Neuro Endocrinol Lett. 2014 Nov 2;35(6):445-453. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25433843

 

Full paper not available yet. I'm reserving judgement until I can see the full paper.

I'd like to know how they have worked out that there were IgA and IgM responses specifically directed against the lipopolysaccharides (LPS) of commensal bacteria.

 

The journal looks trash but I'd be curious to see the full text. Immune responses to commensal bacteria have previously been detected in other conditions like IBD.

 

By chance, I found that vitamin A stops regular diarrhea / loose stools completely. I then learned that vitamin A is important for correct functioning of the immune system in the gut. A relevant article: Vitamin A: The Key to A Tolerant Immune System?

Edit: I take relatively large doses, and not indefinitely. I don't want to give exact recommendations here as there are potential safety issues. I'm not sure how much is required to get an effect either.

 

How much do you take? Thats a big problem for me.
OTH

 

Interesting. When I did a quick search, I found that zinc and vitamin a are really starting to be cutting edge around persistent diarrhea and that there's some promise there.

Next, (After the fiasco of taking folic acid, b6, and cyanocobalamin to lower high homocysteine levels)... does anyone know if there are specific forms to take or NOT to take, or take with/without food, etc... what are the current 'best practices' on taking zinc, vitamin a (and if we know on the methylation process - impacts)...?

 

Thanks, I think I'll give it a go.Ever the optimist OTH

 

I am surprised a mainstream medical journal actually used the phrase "leaky gut". Though I of course don't doubt its existence I have never heard mainstream doctors even here of the terminology.

 

The best shot at getting a copy of the paper is probably to ask M Maes himself...

 

I just did a title search for the phrase 'leaky gut' in Highwire journal database and got 29 hits, including one in PLoS One and 2 in The Lancet.