I thought I was imagining things, but I have noticed that when my friend who is going through methylation for motor neuron disease has a beer, his slurred speech and hoarseness (worse symptoms) seem to clear up for a several words. This has happened 3x. I'm telling him not to drink beer so we can clear out the toxins so he's had few, but maybe we need to rethink this ? What would this point to as far as what is blocking his methylation, supplements that he may need?? He is on MethylB12 and AdB12 (no Hydroxy). Many improvements throughout the body & mind with no start-up or detox symptoms. I was reading other threads about OHCbl and how alcohol inhibits Methionine synthase, but we're having an opposite affect here.. It has to be related somehow, but too complex for me. Something about the brain & the liver. http://forums.phoenixrising.me/show...nversion-of-OH-B12-to-methyl-B12-new-evidence He doesn't get hangovers. Also when he started getting sick, he suddenly had a big intolerance for alcohol, but that has subsided since the B12 methylation. Any insights??