Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
Discuss the article on the Forums.

Estronex Test results

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by globalpilot, Jul 17, 2012.

  1. globalpilot

    globalpilot Senior Member

    Messages:
    626
    Likes:
    256
    Ontario
    I had this test done to see if I had elevated 4-hydroxy estrogen metabolites. I have an upregulated CYP1B1 which metabolizes estrogens down the 4-hydroxy pathway which results in quinones which produce oxidative stress, as opposed to the 2-hydroxy pathway which does not produce the oxidative stress. A great diagram of this produced by Rich V is shown in the xeno-estrogens thread started by Gestalt.

    My results are:
    2-hydroxyestrone (2-OHE1) 10.9 (.2-25.9)
    2-hydroxyestradiol (2-OHE2) 3.3 (.1-11.3)
    4-hydroxyestrone (4-OHE1) .7 (<=3.2)
    16a-hydroxyestrone (16a-OHE1) 12.8 (.2-14.2)
    2-methoxyestrone (2-OMeE1) .8 (.1-6.4)
    4-methoxyestrone (4-OMeE1) <.23 (<=.3)

    To my great surprise the 4-hydroxyestrone was not elevated.
    What I"d really like to know and I'm hoping Rich is reading this - is since the CYP1B1 which converts estrogens into the 4-hydroxy type also is the enzymes that creates quinones - could an upregulation result in normal 4-hydroxy because it is being metabolized to quinones quickly ?
     
  2. cigana

    cigana Senior Member

    Messages:
    970
    Likes:
    782
    UK
    This is a list of substances that down regulate CYP1B1 from my notes (I am also upregulated):
    perhaps you are taking one of these?
     

See more popular forum discussions.

Share This Page