Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Estronex Test results

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by globalpilot, Jul 17, 2012.

  1. globalpilot

    globalpilot Senior Member

    I had this test done to see if I had elevated 4-hydroxy estrogen metabolites. I have an upregulated CYP1B1 which metabolizes estrogens down the 4-hydroxy pathway which results in quinones which produce oxidative stress, as opposed to the 2-hydroxy pathway which does not produce the oxidative stress. A great diagram of this produced by Rich V is shown in the xeno-estrogens thread started by Gestalt.

    My results are:
    2-hydroxyestrone (2-OHE1) 10.9 (.2-25.9)
    2-hydroxyestradiol (2-OHE2) 3.3 (.1-11.3)
    4-hydroxyestrone (4-OHE1) .7 (<=3.2)
    16a-hydroxyestrone (16a-OHE1) 12.8 (.2-14.2)
    2-methoxyestrone (2-OMeE1) .8 (.1-6.4)
    4-methoxyestrone (4-OMeE1) <.23 (<=.3)

    To my great surprise the 4-hydroxyestrone was not elevated.
    What I"d really like to know and I'm hoping Rich is reading this - is since the CYP1B1 which converts estrogens into the 4-hydroxy type also is the enzymes that creates quinones - could an upregulation result in normal 4-hydroxy because it is being metabolized to quinones quickly ?
  2. cigana

    cigana Senior Member

    This is a list of substances that down regulate CYP1B1 from my notes (I am also upregulated):
    perhaps you are taking one of these?

See more popular forum discussions.

Share This Page