I took 1000 mg Inosine m-f last week and felt horrible - flu-like, but tolerable. I'm off it right now and feel ok. I need to deal with my extended family this week because my Dad is sick, so I am not taking it now, but I plan to start a higher dose next week. I read all of your previous comments on inosine and I am hoping my flu-like reaction is a good thing. Let me know if you have any advice or you friend who sees Dr C can give me any info. Thanks!