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Epstein-Barr virus and rheumatoid arthritis

Discussion in 'Latest ME/CFS Research' started by pattismith, Nov 14, 2017 at 2:03 PM.

  1. pattismith

    pattismith Senior Member

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    Epstein-Barr virus and rheumatoid arthritis
    Author links open overlay panel NathalieBalandraudabJeanRoudierab
    August 2017, Pages

    Abstract
    Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, with a 0.5% worldwide prevalence.
    The cause of RA remains unknown, however both genetic and environmental factors may contribute to its development.
    Among these is the Epstein-Barr virus (EBV).
    Here, we discuss several aspects of the close relationship between EBV and RA.
    Patients with RA have impaired control of EBV infection. Indeed, they have high titres of antibodies against EBV antigens. Their peripheral blood T lymphocytes are less efficient at controlling the outgrowth of EBV-infected B cells. RA patients have more EBV-infected B cells than normal controls, leading to a 10-fold systemic EBV overload.

    Post-transplant lymphoproliferative disorder (PTLPD) is a polyclonal EBV-positive B lymphocyte proliferation, which can evolve into an EBV-positive B cell lymphoma.

    RA patients also have an increased risk of developing EBV-associated lymphoproliferative disorder (LPD). Hence the need to monitor EBV load when treating RA patients with immunosuppressors. EBV, a widespread virus, highly recognized by antibodies but never eliminated, is an ideal candidate to trigger chronic immune complex disease.

    Anti-EBV antibody responses should be considered as one of the chronic autoantibody responses linked to the development of RA, in the same way as anti-citrullinated protein antibodies.
     
    Isaiah 58:11, bspg, rosa and 2 others like this.
  2. Gemini

    Gemini Senior Member

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    Thanks for posting this interesting abstract @pattismith.

    Have been curious about B cells ability to harbor EBV, HHV-6, enteroviruses, etc. for some time.

    Always appreciate @Jonathan Edwards thoughts and expertise. Wonder if he would comment on this paper and how this might play a role in ME/CFS and rituximab?
     
    Last edited: Nov 14, 2017 at 6:41 PM
    rosa likes this.

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