http://espace.library.uq.edu.au/eserv.php?pid=UQ:9195&dsID=mp_ebv_04.pdf Reading articles similar to the above and now with the xmrv confirmed negative, although another retrovirus could always be possible, but all us with cfs/me, maybe we have an autoimmune condition combined with immune defiencies(nk and tcell dysfunction) that then leave us open to many different types and combo's of infections. All this can also put us in a viscious circle. That would explain the many partial responses to treatments as i think even the guru docs only really ever go after a few of these issues?? Dr Kogelnik seems onto something with ritux and antivirals. I would love to be inside his brain, although i probably wouldnt have a clue what was going on, i think it would be interesting. Maybe times are changing as Lipkin has mentioned b-cell abnormalities commonly found in auto immunity as well as other immune abnormalities could spurr researchers to start looking deeper or in our case just having a look would be good. What do others think?? cheers!!!