I have been learning a lot about this lately and I thought I would post what I have been learning and some of my thoughts about it. This first post is just an opener, because I am going to try to keep the information in smaller increments. I will add more later and maybe other people will want to add to it also, or correct me if I get something wrong, but let's try to keep it really simple and easy to understand.
**************************************************
I am marking the posts with post numbers so that new people can find the "seminar" posts easily by scanning.
DNA is wrapped around histone, which is sort of like a bunch of scraps of thread rolled in a ball with a lot of tails hanging out.
There is methyl and acetyl stuck on the tails. If there is more methyl on the tails the DNA pulls tighter and there is less gene expression. If there is more acetyl then the DNA is looser and there is more gene expression.
Sirtuins, or sirt1 through sirt7, take acetyl off of the tails, so it causes less gene expression.
LSD1 takes methyl off of the tails, so it causes more gene expression.
If DNA is too tight it is overmethylated and has less expression.
If DNA is too loose it is undermethylated and has more expression.
In this sense, overmethylation and undermethylation have nothing to do with the methylation cycle, which produces SAMe.
**************************************************
I am marking the posts with post numbers so that new people can find the "seminar" posts easily by scanning.
DNA is wrapped around histone, which is sort of like a bunch of scraps of thread rolled in a ball with a lot of tails hanging out.
There is methyl and acetyl stuck on the tails. If there is more methyl on the tails the DNA pulls tighter and there is less gene expression. If there is more acetyl then the DNA is looser and there is more gene expression.
Sirtuins, or sirt1 through sirt7, take acetyl off of the tails, so it causes less gene expression.
LSD1 takes methyl off of the tails, so it causes more gene expression.
If DNA is too tight it is overmethylated and has less expression.
If DNA is too loose it is undermethylated and has more expression.
In this sense, overmethylation and undermethylation have nothing to do with the methylation cycle, which produces SAMe.
Last edited: