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"Enzyme Behind Immune Cell Response Revealed"

Discussion in 'Other Health News and Research' started by ivorin, Oct 13, 2017.

  1. ivorin

    ivorin

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    Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

    Study: https://www.nature.com/articles/s41467-017-01009-1

    Article:
    https://scienmag.com/enzyme-behind-immune-cell-response-revealed/

    Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that although the frequency and phenotype of peripheral B cell subsets seem unaffected, immune responses to T-cell-dependent and -independent antigens are substantially reduced. In vitro activation of Prmt1-deficient B cells with a variety of mitogens results in diminished proliferation, differentiation and survival, effects that are correlated with altered signal transduction from the B cell receptor. Thus PRMT1 activity in B cells is required for correct execution of multiple processes that in turn are necessary for humoral immunity.
     
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  2. aimossy

    aimossy Senior Member

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    From the Introduction:

    From the discussion section:

    Mady Hornig has stated previously (not published) that asymmetric dimethylarginine was notably low in their cohort findings.

     
    Last edited: Oct 13, 2017
    Learner1, pibee, ScottTriGuy and 5 others like this.

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