@eljefe19 I think it is mainly just Dr Paul Cheney who thinks pulsing immunomodulators is important in order not to lose their effect. But I don't think this has been validated in any studies. I seem to remember reading somewhere that some of the Russian interferon inducers stop working after a few days (but I can't seem to find where I read this now — so perhaps I mis-remembered, and am wrong about this). But if some immunomodulators do suffer from a loss of effect after a few days (ie, they stop inducing interferon after a few days), then that would suggest pulsing immunomodulators might be beneficial. Andrographis paniculata and several other supplements may effectively further boost the effects of interferon via their STAT-3 inhibiting effect. STAT-3 blocks effects of interferon in the cell, so interferon will probably work better if you can reduce STAT-3. More info here. I may take some of these STAT-3 inhibitors when I trial interferon suppositories. I am not sure about the benefits of either boosting or inhibiting interferon gamma. It probably depends on the virus you have. Interferon gamma is a type II interferon, and is also a Th1 cytokine (promotes the Th1 response). Whereas interferon alpha, beta and delta are type I interferons. There are plenty of supplements that boost interferon gamma (list here), and Andrographis paniculata inhibits interferon gamma. Interestingly enough, if you look at Dr Chia's tests of different interferon combinations for treating ME/CFS, it was the interferon alpha/gamma combination that put a couple of patients into remission for the longest time (14 months of remission), whereas the interferon alpha/delta combination did not produce any such long lasting remissions (of course, this could just be a random coincidence, as this was a very small scale test). So this perhaps hints that interferon gamma (or interferon gamma inducers) is useful to add to an interferon alpha protocol.