I came across what might be a very significant blog article by Dr Art Ayers about enteroviruses and autoimmunity, in which Ayers states he has detected an amino acid sequence in the VP1 protein of enteroviruses that he also found in all allergens (such as peanut, ragweed, dust mite, bee venom) as well as in the autoantigens of autoimmune diseases like lupus and multiple sclerosis. Persistent enterovirus infection is, of course, strongly linked to ME/CFS, and Dr John Chia found this enterovirus VP1 protein present in ME/CFS patients much more than in health controls (refs: 1 2). So this begs the question: could this possible allergen/autoantigen in enterovirus VP1 protein be the instigating factor for an possible autoimmune state in ME/CFS? The rituximab research is providing evidence that autoimmunity may play a role in ME/CFS. So might Ayers's noting of possible allergen/autoantigen in the enterovirus VP1 protein explain how an autoimmunity in ME/CFS actually arises in the first place? I don't know enough about the complexities of allergens/autoantigens to comment further, but this finding seems interesting.