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Enterovirus VP1 protein contains an allergen that causes autoimmunity?

Discussion in 'Other Health News and Research' started by Hip, Jul 3, 2012.

  1. Hip

    Hip Senior Member

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    I came across what might be a very significant blog article by Dr Art Ayers about enteroviruses and autoimmunity, in which Ayers states he has detected an amino acid sequence in the VP1 protein of enteroviruses that he also found in all allergens (such as peanut, ragweed, dust mite, bee venom) as well as in the autoantigens of autoimmune diseases like lupus and multiple sclerosis.

    Persistent enterovirus infection is, of course, strongly linked to ME/CFS, and Dr John Chia found this enterovirus VP1 protein present in ME/CFS patients much more than in health controls (refs: 1 2).

    So this begs the question: could this possible allergen/autoantigen in enterovirus VP1 protein be the instigating factor for an possible autoimmune state in ME/CFS?

    The rituximab research is providing evidence that autoimmunity may play a role in ME/CFS. So might Ayers's noting of possible allergen/autoantigen in the enterovirus VP1 protein explain how an autoimmunity in ME/CFS actually arises in the first place?

    I don't know enough about the complexities of allergens/autoantigens to comment further, but this finding seems interesting.
     
    Last edited: Sep 14, 2014
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  2. ukxmrv

    ukxmrv Senior Member

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    Very interesting Hip. The first test for the VP1 protein I came across was through Prof Mowbray at St Mary's in London. He carried out tests on ME patients in the late 80's I think. I remember having the test (It was a blood test then) and ME Association canvassed members to see what the results were.
    There was a large body of work and thought about entroviri in the UK then.
     
  3. Hip

    Hip Senior Member

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    Yes, Dr Chia has been handed the baton, so to speak, of enterovirus ME/CFS research — research which was originally pioneered by Prof James Mowbray and Dr John Richardson. Richardson had over 50 years of clinical experience of enterovirus-triggered ME/CFS, I understand.
     
  4. Enid

    Enid Senior Member

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    I do agree and am sure this line of research is one our best for ME. Thanks for posting Hip.
     
  5. Hip

    Hip Senior Member

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    Actually, I am going to post the above-mentioned blog article by Dr Art Ayres here, for ease of reference:

    Source: http://coolinginflammation.blogspot.co.uk/2009/03/enteroviruses-autoimmunity-diabetes.html
     
    Last edited: Sep 14, 2014
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  6. Emootje

    Emootje Senior Member

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    Enteroviruses are also connected to rheumatic heart disease:

    "Changes in heart valves of mice or monkeys following experimental enterovirus infection closely resemble human chronic rheumatic heart disease and viral antigens or particles were found in these pathological valves...In conclusion, this study is the first demonstration of enterovirus replication in valvular tissue from chronic rheumatic heart disease and provides new evidence to support an aetiological role of these viruses in some case"
    Enterovirus replication in valvular tissue from patients with chronic rheumatic heart disease.

    Probably the cause of my heart valve abnormality...
     

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