Enterovirus 71 infection, although often asymptomatic or mild, occasionally causes severe neurological symptoms such as meningitis, encephalitis, and poliomyelitis-like paralysis. This virus tends to appear in epidemics that affect children. The mechanism by which this virus can cause neurological destruction is not well understood, so the authors of the following study set out to see if IgG antibodies induced by enterovirus 71 infection might be cross-reactive to proteins in the brain tissue: The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments. Feb 2010. They found that in mice, enterovirus 71 seems induce IgG antibodies that can target the tissues of the cerebrum. What's more, these antibodies were able to cross the blood-brain barrier and enter the brain. I wonder if something similar might happen with the enteroviruses associated with ME/CFS, namely coxsackievirus B and echovirus. Could these be inducing IgG antibodies that cross-react with brain tissue, thereby leading to ME/CFS symptoms? @Jonathan Edwards, this looks to be the molecular mimicry-type model of autoimmune attack, which you generally do not support; so it would be good to have your views on the above study.