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Enhanced susceptibility of T lymphocytes to oxidative stress in the absence of the cellular prion pr

Discussion in 'Other Health News and Research' started by lansbergen, Jan 23, 2013.

  1. lansbergen

    lansbergen Senior Member


    Enhanced susceptibility of T lymphocytes to oxidative stress
    in the absence of the cellular prion protein

    Catherine Aude-Garcia • Christian Villiers • Serge M. Cande´ias •
    Catherine Garrel • Caroline Bertrand • Ve´ronique Collin • Patrice N. Marche •
    Evelyne Jouvin-Marche

    Accepted: 21 July 2010 Springer Basel AG 2010


    The cellular prion glycoprotein (PrPC) is
    ubiquitously expressed but its physiologic functions remain
    enigmatic, particularly in the immune system. Here, we
    demonstrate in vitro and in vivo that PrPC is involved in T
    lymphocytes response to oxidative stress. By monitoring
    the intracellular level of reduced glutathione, we show that
    PrP-/- thymocytes display a higher susceptibility to H2O2
    exposure than PrP?/? cells. Furthermore, we find that in
    mice fed with a restricted diet, a regimen known to increase
    the intracellular level of ROS, PrP-/- thymocytes are more
    sensitive to oxidative stress. PrPC function appears to be
    specific for oxidative stress, since no significant differences
    are observed between PrP-/- and PrP?/? mice exposed to
    other kinds of stress. We also show a marked evolution of
    the redox status of T cells throughout differentiation in the
    thymus. Taken together, our results clearly ascribe to PrPC
    a protective function in thymocytes against oxidative

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