1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Join the National PR Campaign for ME: Power to the Patient (P2tP)
Have you had enough of all the neglect and abuse of ME/CFS patients? Gabby Klein says now is the time for a National PR Campaign for ME/CFS to impress a change. Join the Patient Revolution to restore power to ME patients ...
Discuss the article on the Forums.

Engineered Stem Cells: A Treatment For Heart Attacks?

Discussion in 'Other Health News and Research' started by Rosemary, Jul 21, 2010.

  1. Rosemary

    Rosemary Senior Member

    Messages:
    193
    Likes:
    0
    Engineered Stem Cells: A Treatment For Heart Attacks?

    (Ivanhoe Newswire) -- Engineered stem cells reduced organ damage and led to better cardiac function after a heart attack, according to a recent study conducted in animals.

    This study was designed to help determine the role cytokines -- substances secreted by cells that have an effect on other cells -- might play following a heart attack.

    Researchers from Germany implanted five groups of 10 rats with tiny polyurethane scaffolds, which were seeded with different genetically-engineered stem cells. Three groups received cells that overproduced one of three cytokines: hepatocyte growth factor (HGF), stromal cell-derived factor 1 (SDF-1) or vascular endothelial growth factor (VEGF). One group received a gene called Akt1, which is associated with cytokine pathways. Another group received scaffolds seeded with unmodified stem cells. Five more groups were injected with the same types of modified and unmodified stem cells without the plastic scaffolding. An 11th group received a sham treatment.

    During six weeks of follow-up, investigators saw significant improvements in blood pressure function among the rats implanted with scaffolds seeded with stem cells modified to overproduce Akt1, SDF-1 and HGF. SDF-1 and Akt1 also seemed to limit cardiac damage from the heart attack. Researchers noted there was a decrease in blood pressure function in the control group, which received sham procedures.

    SOURCE: American Heart Association's Basic Cardiovascular Sciences 2010 Scientific Sessions -- Technological and Conceptual Advances in Cardiovascular Disease, July 21, 2010
     

See more popular forum discussions.

Share This Page