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Energizing sick mitochondria with vitamin B3.

Discussion in 'General Treatment' started by Ema, Apr 8, 2014.

  1. Ema

    Ema Senior Member

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    Hmmm, good for mitochondria...and for killing antibiotic resistant infections.

    Time to get out the nicotinamide again, I think!

    Energizing sick mitochondria with vitamin B3: Effective treatment for mitochondrial disease
    Date:
    April 7, 2014

    Source:
    Helsingin yliopisto (University of Helsinki)

    The researchers of the University of Helsinki, Finland, and École Polytechnique Fédérale de Lausanne, Switzerland, have shown that vitamin B3 form nicotinamide riboside can slow down the progression of mitochondrial disease, suggesting its potential as a novel therapy approach to adult-onset mitochondrial muscle diseases.

    Vitamins B have recently been turned out to be potent modifiers of energy metabolism, especially the function of mitochondria. Vitamin B3, (niacin) has been found to delay the signs of aging in animal models.

    An international collaboration between the University of Helsinki and École Polytechnique Fédérale de Lausanne reported today in the journal Embo Molecular Medicine that vitamin B3 form, nicotinamide riboside, can slow down the progression of mitochondrial disease, suggesting its potential as a novel therapy approach to adult-onset mitochondrial muscle diseases.

    Mitochondria power up all cells in our bodies, by generating fuel, ATP, for all cellular functions. Dysfunction of these cellular engines can cause mitochondrial disorders, which are the most common cause of inherited metabolic diseases in adults and children. Mitochondrial myopathy is the most frequent form of adult mitochondrial disorder. The typical symptoms in the patients are muscle weakness, pain and cramps. Despite the progressive nature of these diseases, no curative treatment is available.

    In their current publication, Dr Nahid Khan in Prof Anu Suomalainen Wartiovaara's group showed that feeding mice with food supplemented with B3 form, nicotinamide riboside, delayed their mitochondrial myopathy. The treatment increased mitochondrial mass and function, and cured the structural abnormalities. These results clearly showed the potential of this vitamin B form, a natural constituent of milk, to activate dysfunctional mitochondrial metabolism.

    "These results are a breakthrough for understanding the mechanisms of human mitochondrial muscle diseases and for exploring the efficient treatment options for these progressive disorders of adults. They also highlight the potent role of niacin in guiding mitochondrial energy metabolism," Professor Anu Suomalainen Wartiovaara states.

    Story Source:

    The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.

    Journal Reference:

    1. Nahid A Khan, Mari Auranen, Ilse Paetau, Eija Pirinen, Liliya Euro, Saara Forsström, Lotta Pasila, Vidya Velagapudi, Christopher J Carroll, Johan Auwerx and Anu Suomalainen. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO Molecular Medicine, April 2014 DOI: 10.1002/emmm.201403943
     
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  2. Ema

    Ema Senior Member

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    Look, @heapsreal, it says it is insulin-sensitizing!



    Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0.
    Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.
    Chi Y1, Sauve AA.
    Author information

    Abstract
    PURPOSE OF REVIEW:
    This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitamin B3. We review knowledge of the metabolism of this substance, as well as recent work suggesting novel health benefits that might be associated with nicotinamide riboside taken in larger quantities than is found naturally in foods.

    RECENT FINDINGS:
    Recent work investigating the effects of nicotinamide riboside in yeast and mammals established that it is metabolized by at least two types of metabolic pathways. The first of these is degradative and produces nicotinamide. The second pathway involves kinases called nicotinamide riboside kinases (Nrk1 and Nrk2, in humans). The likely involvement of the kinase pathway is implicated in the unique effects of nicotinamide riboside in raising tissue NAD concentrations in rodents and for potent effects in eliciting insulin sensitivity, mitochondrial biogenesis, and enhancement of sirtuin functions. Additional studies with nicotinamide riboside in models of Alzheimer's disease indicate bioavailability to brain and protective effects, likely by stimulation of brain NAD synthesis.

    SUMMARY:
    Initial studies have clarified the potential for a lesser-known Vitamin B3 called nicotinamide riboside that is available in selected foods, and possibly available to humans by supplements. It has properties that are insulin sensitizing, enhancing to exercise, resisting to negative effects of high-fat diet, and neuroprotecting.
     
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  3. adreno

    adreno 3% neanderthal

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    Yeah, this is not regular nicotinamide.
     
  4. Ema

    Ema Senior Member

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    I know...it's EXPENSIVE nicotinamide. :(

    But you should get all the same benefits of regular nicotinamide from it as well as the ones you get from the "special" form.
     
  5. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    is there are recommended dose of nicotinamide?
     
  6. Ema

    Ema Senior Member

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    Not that I can find yet...but I haven't got the full text of the second paper yet.

    I emailed you the first paper, just FYI.
     
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  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    ote="Ema, post: 450984, member: 4199"]Not that I can find yet...but I haven't got the full text of the second paper yet.

    I emailed you the first paper, just FYI.[/quote]
    Could it be this improvement in mitochondria as to why b3 helps lower cholesterol? ?
     
  8. Cheesus

    Cheesus Senior Member

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    Doesn't regular niacinamide do the same? Dr Myhill thinks very highly of it...

    EDIT: Just re-read the above study and realised it is talking about a very specific action. Never mind.
     
  9. adreno

    adreno 3% neanderthal

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    Looks like regular Niacinamide would be helpful too :

     
  10. Hanna

    Hanna Senior Member

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    When I was on Dr Myhill's Protocole, I used to take 500 mg Niacinamide 3 times a day. Didn't see any progress, but that was four years ago... It seems to me that 25 mg of active B3 (NAD) has some more effects now.
     
  11. adreno

    adreno 3% neanderthal

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    Really there needs to be a balance between B3 (NAD) and methyl groups. Methylation cranks up metabolism and hence oxidative stress, whereas B3 decreases it. Both hypo- and hypermethylation is bad for you.
     
  12. Ema

    Ema Senior Member

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    This article used doses in mice from 250 mg/kg to 400 mg/kg which works out to about 1200 mg/day in a 60 kg human at the low end and just under 2000 mg/day at the high end.

    Considering a bottle of sixty 250 mg capsules is $50...this could get to be an expensive proposition indeed. If it works, even.

    Why are all the mito supps so expensive??
     
  13. rwac

    rwac Senior Member

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    I've been following this stuff. It was about $18 per bottle a little while ago, and will probably fall in price once the great houha (it potentially extends lifespan and improves cognition) dies, possibly even cheaper since lots of people will be buying it.
     
  14. Ema

    Ema Senior Member

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    So the bottle arrived today...and the serving size is TWO capsules...so each one is actually 125 mg.

    That really pisses me off when companies do that. I mean, really, CAN YOU JUST PUT THE AMOUNT IN ONE PILL ON THE LABEL???

    Ugh, rant.

    This stuff better be magic but unfortunately I've tried one too many "magic" supps to have a whole lot of hope left...
     
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