Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Endothelial nitric oxide increased in Normal Flow POTs

Discussion in 'Problems Standing: Orthostatic Intolerance; POTS' started by ramakentesh, Oct 25, 2011.

  1. ramakentesh

    ramakentesh Senior Member

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    Hi this may be of interest, a subset of POTS patients that appear to have too much endothelial and neuronal nitric oxide resulting in blood pooling specific to the stomach region. This could potentially explain B12 efficacy in some forms of POTS/CFS as it is a potent scavenger and potential competitor of NO.

    http://ajpheart.physiology.org/content/301/3/H704.abstract

    Strange thing is, another major subset of POTS seems to have elevated angiotensin and REDUCED neuronal nitric oxide bioavailability.
     

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