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Endogenous retroviruses/potential hazards for vaccines

Discussion in 'XMRV Research and Replication Studies' started by FernRhizome, Apr 10, 2010.

  1. FernRhizome

    FernRhizome Senior Member

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    Any of you good science folks able to help us interpret this one? Does anyone have access to the full paper? How does this connect to
    1) the current ancient retrovirus study from Chicago/Tufts that some of us are participating in
    2) pet transmission
    3) vaccines
    4) XMRV? ~fern

    Biologicals. 2010 Apr 7. [Epub ahead of print]
    Endogenous retroviruses as potential hazards for vaccines.
    Miyazawa T.
    Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan.
    Abstract
    Retroviruses are classified as exogenous or endogenous according to their mode of transmission. Generally, endogenous retroviruses (ERVs) are not pathogenic in their original hosts; however, some ERVs induce diseases. In humans, a novel gammaretrovirus was discovered in patients with prostate cancer or chronic fatigue syndrome. This virus was closely related to xenotropic murine leukemia virus (X-MLV) and designated as xenotropic murine leukemia virus-related virus (XMRV). The origin and transmission route of XMRV are still unknown at present; however, XMRV may be derived from ERVs of rodents because X-MLVs are ERVs of inbred and wild mice. Many live attenuated vaccines for animals are manufactured by using cell lines from animals, which are known to produce infectious ERVs; however, the risks of infection by ERVs from xenospecies through vaccination have been ignored. This brief review gives an overview of ERVs in cats, the potential risks of ERV infection by vaccination, the biological characteristics of RD-114 virus (a feline ERV), which possibly contaminates vaccines for companion animals, and the methods for detection of infectious RD-114 virus. Copyright 2010 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
    PMID: 20378372 [PubMed - as supplied by publisher]

    http://www.ncbi.nlm.nih.gov/pubmed/20378372
     
  2. Gerwyn

    Gerwyn Guest

    retroviruses are either endogenous or exogenous based on whether they are replicative or not.Exogenous viruses can be transmitted vertically or horizontally.Endogenous viruses can only be transmitted vertically and are not infectious.

    No XMRV was not derived from an endogenous virus but an exogenous Mulv which jumped species.This is called zoonosis.There is no such thing as an inectious erv otherwise by definition it would not be an erv.X_Mlv,s are not ervs of mice of any kind.XMRV can no longer infect mice and have not been able to do so for about 60 years.
     
  3. julius

    julius Watchoo lookin' at?

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    "however, some ERVs induce diseases."

    I don't get it. Is Miyazawa wrong then?
     
  4. FernRhizome

    FernRhizome Senior Member

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    Right, it sounds to me like X-MLV did jump. I think, maybe from the abstract, it was thought that X-MLV was THOUGHT to not be able to jump, but then it did. That's why it wasn't discovered earlier, no one thought it could do the jump. So am I interpreting the extract right that the author is postulating that it might have jumped into cats via pet vaccinations? Or that this is a potential area to explore? I think we need access to the entire paper to know for sure. Can anyone get it? ~Fern
     
  5. JillBohr

    JillBohr Senior Member

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    Fern, I interpreted this paper the same way you did. They thought it could not jump but it did. However, I am not very smart when it comes to science. I was great in math and business but that is it. I hope someone will post the whole paper and the smart people here that know what they are doing can comment on it. This looks very interesting.

    One more thing, I cannot access the library here and there have been several occasions when someone did post a paper and I could not access it. Is there anyway to change that?
     
  6. JillBohr

    JillBohr Senior Member

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    It looks like this paper is a follow up on where they did find an endogenous retrovirus in a live vaccine for pets.
    http://jvi.asm.org/cgi/content/abstract/JVI.02715-09v1

     
  7. Gerwyn

    Gerwyn Guest

    hi Julius
    to date Hervs have not been shown to cause any human diseases quite the reverse.protein expression is found in a number of illbesses such as RA.Ervs are expreesed as part of the intrisic defences and thus far they have not been shown to cause any human diseases
     
  8. Gerwyn

    Gerwyn Guest

    all exogenous retoviruses have the potential to jump back and fore between mammalian species.

    The mechanism appeard to be achieved by incoporating ERV proteins into their coat as substituting a protein in the receptor specific area.

    This changes the shape of the viral envelpoe so it can no longer infect its current host but can engage with cellular receptors of another species and infect them instead
     
  9. natasa778

    natasa778 Senior Member

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    there is a long thread on this topic of contamination titled "Mouse retrovirus in production of biologicals in "XMRV Testing, treatment and transmission" section.
     
  10. natasa778

    natasa778 Senior Member

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    No.

    Gerwyn explained why, ERVs are not infectious in host species (according to current science) but can become that, once they cross species. Once they do they are not ERVs (endogenous) to that new host.
     
  11. JillBohr

    JillBohr Senior Member

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    So..... the XMRV is an extrogenous virus which is dangerous. Right? So sorry but I am having difficulty wrapping my brain around this. Honestly, I did not know any of these terms until recently. I was so happy to get my 15 credit hours of science BER's when I was a college student and I never thought I would ever have to deal with science again once I got out. Oy!
     
  12. gracenote

    gracenote All shall be well . . .

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    Hi Jill,

    You will have access to the library when you reach 100 posts; you only have 9 to go. Or, you can request admission from a moderator.
     
  13. JillBohr

    JillBohr Senior Member

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    Thank you Gracenote. I am working on this today so hopefully I will have access by tomorrow. Yeah!
     
  14. JillBohr

    JillBohr Senior Member

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    Thank you Gracenote! I am working on this today. Hopefully I will have access by tomorrow. Yeah!
     
  15. Bob

    Bob

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    Gerwyn, hasn't there been some research that demonstrates that endogenous retroviruses can become infectious again?...
    www.ncbi.nlm.nih.gov/pmc/articles/PMC2648265/?tool=pubmed

    Previously discussed on the forum here:
    http://www.forums.aboutmecfs.org/sh...-recombination-and-relevance-for-xmrv-in-xand

    Also, I understood that the original mouse virus is endogenous in mice... isn't that the case?

    It is thought that the RNA/DNA of an endogenous animal virus could be present in vaccines and that could be a route for the virus to jump species and mutate.
     
  16. kurt

    kurt Senior Member

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    Gerwyn, do you have a reference for this? I have read a number of papers suggesting exactly the opposite. The research evidence for specific mechanisms is growing, what do you mean by 'they have not been shown' - absolute proof may be lacking still but the idea that HERVs can be involved in disease is far from disproven.

    Here is an example of the literature, this is older, but a good synopsis, there is an extensive literature since this time.

    The full paper is available free here:

    Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease.
     
  17. Gerwyn

    Gerwyn Guest

     
  18. Gerwyn

    Gerwyn Guest

     

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