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Endogenous retrovirus(es) causing unexplained illnesses?

Discussion in 'Other Health News and Research' started by sensing progress, Jan 18, 2011.

  1. sensing progress

    sensing progress Senior Member

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    Tucson, AZ
    I read a fascinating article in last summer's Discover Magazine that I thought might have implications for ME/CFS. The article is about how both Schizophrenia and MS are linked to the same human endogenous retrovirus. If XMRV doesn't turn out to be "it" for ME/CFS/FM/etc, maybe something similar will turn up. What's fascinating is that the researcher did not start by looking for any particular agent, but rather studied the CSF of patients for reverse transcriptase enzyme activity. When that was found, they were able to work backwards and discovered HERV-W (human endogenous retrovirus "W"). Very interesting stuff.

    http://discovermagazine.com/2010/jun/03-the-insanity-virus/article_print
     
  2. Marco

    Marco Grrrrrrr!

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    Near Cognac, France
    Fascinating

    Very similar to the work Brigitte Huber is doing on HERV K18 and she is very aware of the HERV Multiple Sclerosis connection.

    I appreciate that Brigitte Huber isn't exactly flavour of the month at the moment but I'm sure there could be a very fruitful collaboration between her and GeNeuro.

    I particularly like the technique to determine the presence of any retrovirus, even if not previously catalogued, rather than looking for a specific suspect. Wasn't there any other thread recently where a similar technique was used?

    Who knows. Maybe its XMRV and not EBV or HHV6 that reactivates HERVs?
     
  3. leela

    leela Slow But Hopeful

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    Great article sensing, which I would think could apply to endogenous or exogenous viruses.

    The following passage IMO speaks volumes for the correct approach in looking at all the illnesses associated with XMRV--
    why some get GWS, some ME, some Lyme, some Autism etc. It's the internal and external environmental conditions that
    determine the immune response to the pathogen, which in turn determines how the disease pattern manifests.
    The bit I bolded also deserves consideration.

     
  4. leaves

    leaves Senior Member

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    Any news on Huber's study'
     
  5. undcvr

    undcvr Senior Member

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    The small problem here is that the ARVs that we now hv on the mrkt, even those that are supposed to work in vivo on XMRV, it does not seem like they work on the HERVs or that recovery rates on ARVs are high.

    It seems easier to go the herpesvirus route where, silencing them, seems to silence the RV as well.
     

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