I had a shot of Enbrel two weeks ago on Tuesday. The past couple days I've been feeling absolutely awful. I've been itching all over, unable to sleep and having chills or overly hot. Last night, after another night of not sleeping and itching from head to toe I woke up this morning with a huge welt on my leg where the shot was given of Enbrel. I had to call the rheumatologist. Now on prednisone. She said she never heard of a delayed reaction after two weeks. I swear to God I am the weirdest person that exists when it comes to medications and my body. I quit. I've been in bed this whole weekend, itching from head to toe. I'm to stop Enbrel. There really are no other treatments for SS after this other than methotrexate, which I will not do.