As we know, a significant percentage; one third of the patients, in Mella/Fluge's study didn't respond to RTX. And what the science team is doing next, is a study on Enbrel. Mella/Fluge writes the following: There are no published scientific published study that evaluated the use of Enbrel in CFS / ME. However, there is a contemporaneously where six CFS / ME patients had been treated with etanercept with good clinical effect, but these results have not been published later (Lamprecht K. American Association of Chronic Fatigue Syndrome, Seattle 2001). In addition, individual patient unpublished stories available (link). 'Kristin' says the following about Enbrel: "I was in a “pre-study” with Enbrel back in 2000. I have CFS-moderate. For the first weeks-nothing. Week 5-8 I felt wonderful. Not completely normal, but SO much better. I cried when I had to stop at 8 weeks and found out the cost of Enbrel. What I would not give to see Enbrel further studied and approved for CFS treatment. (link)" I'd like to open a thread, brainstorming for reasons it might be effective/not be effective, and arguments one could use for getting on it.