The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Emory finds XMRV in prostate cancer

Discussion in 'XMRV Research and Replication Studies' started by cigana, Mar 9, 2011.

  1. cigana

    cigana Senior Member

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  2. Christopher

    Christopher Senior Member

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    Don't you read the newspaper? XMRV is a contaminant. :p
     
  3. cigana

    cigana Senior Member

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    Oops, guess I just don't understand the meaning of a "blinded" test...:D
     
  4. ixchelkali

    ixchelkali Senior Member

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    An antibody test for XMRV would be nice, since viremia seems to drop to near nothing soon after the initial infection (at least in the macaque study). I can't help but think the low viral load may be one factor that's plaguing the blood test/PCR studies. Maybe an antibody test would get around that problem.
     
  5. Jemal

    Jemal Senior Member

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    I like this. I like this a lot!

    Bombshell!

    Anyway, most of the research talked about is now older. I am curious, what is their stance towards the contamination issues?
     
  6. cigana

    cigana Senior Member

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    Since their tests were blinded, that would prove that contamination was not possible...
     
  7. August59

    August59 Daughters High School Graduation

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    I think something in PWC's is allowing XMRV to start replicating again once it has entered our body and spread to the various reservoirs. A genectic fault or a co-infection probably to do with APOBEC3?

    We need to call Emory though and tell them throw all their prostate samples away because they are contaminated and spewing xmrv!! Apparently their samples were not spewing XMRV or they would not have had to look so hard to find it?!? (Using the word "spewing" sarcastically and not picking on Cort or the use of it from his article on contamination)
     
  8. toddm1960

    toddm1960 Senior Member

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    I really think the only way positive studies are going to be released is via the internet, negitive studies are published in days. Easy to see how the 1991 virus was buried.
     
  9. August59

    August59 Daughters High School Graduation

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    Very easy to see. Good point.
     
  10. Gemini

    Gemini Senior Member

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    cigana,

    Thanks for posting!

    Excellent summary of XMRV studies by seven Emory labs!

    Researchers are asking the right questions, i.e.:

    “My interest now is to understand why some drugs that work against HIV work against XMRV and others don’t,” continues Schinazi. “I’m also interested in discovering the method of transmission. And what happens in the brains of patients who are infected. There is a lot of interesting work yet to be done.”

    They have the skills, retroviral experience(HIV), and resources for XMRV research, plus their labs collaborate!

    Impressive and encouraging!
     
  11. ixchelkali

    ixchelkali Senior Member

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    I don't think patients develop antibodies to a lab contaminate. That's one thing that makes an antibody test so sweet.
     
  12. Cloud

    Cloud Guest

    Some of the folks at WPI have seen enough over the years to know that anything advancing the truth about ME/CFS, will surely be attacked and discredited.....especially anything to do with an infectious cause. Dr Peterson has been ground zero front lines brunt of that storm from the start. WPI knew full well this onslaught of opposition would happen. I would suspect they had devised a covert plan much before October 2009, in preparation for the political storm that was sure to come. Maybe we are seeing some evidence of that plan with the Norway study, and others that cannot be suppressed. Dr Judy did say last month that the "politics will soon go away".
     
  13. Forebearance

    Forebearance Senior Member

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    Wow! What a great article. It makes me so happy that they have developed their own antibody test. It can only help to have more diagnostic tests that work.
     
  14. kurt

    kurt Senior Member

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    From that article:

    That pretty much rules out XMRV as causative for CFS in my opinion, as CFS is not likely an STD. At least not in the majority of cases, not in the outbreaks, not in many cases I am familiar with. And that is an equally ridiculous statement for prostate cancer, there is not a significantly higher rate of prostate cancer among more sexually active or non-monogamous people. In fact, I believe research shows the opposite.

    Small number so not statistically significant, and re-use of the same patient samples to create the 'blinded' tests. So if there was contamination, they just proved that it was consistent (concordant results) several times over in the separate labs.

    In my view, this is the big picture. When evidence is mounting to support both sides of a scientific argument, there is a long way to go still.
     
  15. cigana

    cigana Senior Member

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    Too right. And to think they didn't have the internet then either...
     
  16. SilverbladeTE

    SilverbladeTE Senior Member

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    Kurt
    it's a retrovirus AND we don't know it's full nature, nto even close
    what if it was initially spread sexually/blood or even insaliva...but then since it's a retrovirus...it passes to offspring, and after a certian time the virus is no longer capable of being spread sexually (or very little chance) because it has "buried" itself inside tissue and not fluids etc?

    there DOES seem to be cases of transmission or ME by close contact, this has ot be explained somehow.

    Remember unlike most STDs or quickly lethal/obvious pathogens, you are going ot have one hell of a time sorting out the epidemiology of a disease that can affect people in many different ways with a long incubation period and pehraps no obvious link to originator and no actual test for the pathogen!
     
  17. cigana

    cigana Senior Member

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    Not in the outbreaks, but I don't see why XMRV can't be transmitted sexually in other cases.

    According to Dr Eric Klein epidemiological data shows there is a higher rate among people with more sexual partners and an increased risk with early sexual activity.
    Good point, but wasn't one of the tests for antibodies?
     
  18. Jemal

    Jemal Senior Member

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    XMRV might need a trigger, before your body develops something like CFS. So in the cases of the outbreaks, all these people might already have had XMRV and they only got CFS once some kind of trigger was pulled. Maybe another virus going around at that time, like the flu. Or exposure to a certain mold.

    We know from other retroviruses that they can also spread by saliva (AND it could still be an STD as well).

    I still think CFS is more like an autoimmune disorder: somewhere along the line you get infected with XMRV. Then something happens that makes the immune system recognize your body has been infected with XMRV and starts attacking it. This develops into something like CFS. We share many of our symptoms with autoimmune disorders, like the fatigue and muscle aches. Depending on where XMRV is located in your body, the immune response could trigger all kinds of symptoms.
    XMRV itself might be innocent, so it might not cause problems on its own. It's likely though it does cause problems, like cancer. I still like this article a lot:

    http://niceguidelines.blogspot.com/2010/12/my-take-on-cfs-xmrv-as-of-today.html

    and

    (All theory of course).
     
  19. cigana

    cigana Senior Member

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    I think that's almost certainly the case.
     
  20. SilverbladeTE

    SilverbladeTE Senior Member

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    In effect a "binary illness", requiring two or more agents to work off each tother, triggering a persistant illness state either by their own actions and/or triggering auto-immune perpetuation.
    this has been talked about for a long time as a possibility with ME/CFS, but how this actually comes about is perhaps becoming something we can soon grasp .

    Alas, we still have too many morons in the medical arena (and others) who see the world in most basic, infantile reductionist simplicty:
    ie 1 disease = can only have 1 cause, and one causative agent can have only 1 effect in their view.
    which flies in the face of reality (which is full of complex interactions, even symbiosis, and synergies).
     

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