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California 2014: IACFS/ME Day Two: Translating Science into Clinical Care: 21 March 2014
Searcher kicks us off on Day Two, with an autoimmunity overview, then we are into immunology and cytokines, we hear from Susan Levine and the allergy-related signatures study done with Lipkin et. al, a talk about paravirus B-19, Mady Hornig from CFI with more research, John Chia who...
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Emerging Role of Autoimmunity in ME/CFS

Discussion in 'Latest ME/CFS Research' started by MeSci, Sep 27, 2013.

  1. MeSci

    MeSci Activity level: 6

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    Cornwall, UK
    Just the abstract so far:


    SickOfSickness, allyb, Tito and 5 others like this.
  2. Marlène

    Marlène Senior Member

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    Edegem, Belgium
    Tnx, I will send this to my rheumatologist.
    aimossy likes this.
  3. A.B.

    A.B. Senior Member

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    I'm VERY interested in the full article, but don't want to pay for it. Has anyone been able to find a copy somewhere on the internet?
    aimossy and allyb like this.
  4. Bob

    Bob

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    allyb likes this.
  5. nandixon

    nandixon Senior Member

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    aimossy and A.B. like this.
  6. aimossy

    aimossy Senior Member

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    This is soooooo worth reading and taking in, I have only read parts and can't take it in properly.I wonder what professor Edwards makes of it. Or anyone who has the good science brain!
    There is lots to take in.:)
    rosie26 likes this.
  7. Jonathan Edwards

    Jonathan Edwards Senior Member

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    I had a look at the paper. The introductory sections give quite a good review of some of the evidence for autoimmunity being relevant to ME. Later sections of the paper, however, seem to focus on fashionable ideas that have largely proved unhelpful, or at least never really made sense and never been supported by any evidence, to my way of thinking - molecular mimicry, T cell autoreactivity and a non-antibody mediated role for B cells. They actually quote our use of rituximab as support for the idea that there is a non-antibody mediated role for B cells but the data from use of rituximab are clearly against this conclusion. The delayed response indicates an effect on autoantibody levels, not help to T cells. Sadly this seems to be a rewrite of the received wisdom that gets perpetuated in the review journals. Still, at least I am all in favour of airing of ideas about autoimmunity in ME.
    MeSci, justy, aimossy and 1 other person like this.

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