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Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. This second article in a 2-Part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS....
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Emerging Role of Autoimmunity in ME/CFS

Discussion in 'Latest ME/CFS Research' started by MeSci, Sep 27, 2013.

  1. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Cornwall, UK
    Just the abstract so far:


     
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  2. Marlène

    Marlène Senior Member

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    Edegem, Belgium
    Tnx, I will send this to my rheumatologist.
     
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  3. A.B.

    A.B. Senior Member

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    I'm VERY interested in the full article, but don't want to pay for it. Has anyone been able to find a copy somewhere on the internet?
     
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  4. Bob

    Bob

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    South of England
    You can read the first two pages for free here, if you click on 'look inside' at top-right of webpage:
    http://link.springer.com/article/10.1007/s12035-013-8553-0#page-1
     
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  5. nandixon

    nandixon Senior Member

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    aimossy and A.B. like this.
  6. aimossy

    aimossy Senior Member

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    This is soooooo worth reading and taking in, I have only read parts and can't take it in properly.I wonder what professor Edwards makes of it. Or anyone who has the good science brain!
    There is lots to take in.:)
     
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  7. Jonathan Edwards

    Jonathan Edwards Board Member

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    I had a look at the paper. The introductory sections give quite a good review of some of the evidence for autoimmunity being relevant to ME. Later sections of the paper, however, seem to focus on fashionable ideas that have largely proved unhelpful, or at least never really made sense and never been supported by any evidence, to my way of thinking - molecular mimicry, T cell autoreactivity and a non-antibody mediated role for B cells. They actually quote our use of rituximab as support for the idea that there is a non-antibody mediated role for B cells but the data from use of rituximab are clearly against this conclusion. The delayed response indicates an effect on autoantibody levels, not help to T cells. Sadly this seems to be a rewrite of the received wisdom that gets perpetuated in the review journals. Still, at least I am all in favour of airing of ideas about autoimmunity in ME.
     
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