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Elevated plasma biomarkers of chronic inflammation in Gulf War illness (591.3)

Discussion in 'Other Health News and Research' started by Bob, Sep 1, 2014.

  1. Bob

    Bob

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    This is from April 2014, but I've not seen it before...

    Elevated plasma biomarkers of chronic inflammation in Gulf War illness (591.3)
    Gerhard Johnson, Billie Slater, Linda Leis and Ronald Bach.
    April 2014
    The FASEB Journal
    http://www.fasebj.org/content/28/1_Supplement/591.3.short

     
    Last edited: Sep 1, 2014
    Kati, morse27, xchocoholic and 4 others like this.
  2. redrachel76

    redrachel76 Senior Member

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    Gulf War illness is put here as a separate illness to ME/CFS. I wonder if it is the same thing.
    If not, then it must be very similar.
     
    morse27 likes this.
  3. lnester7

    lnester7 Seven

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    What I understand is that the cytokines profile of gws is different than those w Cfs but I do not know specific markers, I do remember one person in pR saying that Klimas told her she looked more like a gws patient more than Cfs. I forgot who that was by now. But if you look for Klimas videos she talks about differences and similarities.
     
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  4. morse27

    morse27 Senior Member

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    i have the "war gulf illness" , i try RITUXAN treatment for ME/CFS , 3 infusions since december, i received "squalen" adjuvant in vaccine , difference with CFS/ME for mens : impotence , paresthesia in hands for 18 months, anti bodies to squalen (pamela Asa , Tulane school ) , no deep sleep (N3 and N4) ,totall insomnia, gastro intestinal disorder with strongly SIBO test after 45 minutes, i have not NK cell low level , but high : CD16 + CD56 at 26% ( 4 - 25% normal), CD3 + cells at 826 (low) , so , if i have a good response with Rituximab, it will be possible to cure all war gulf veterans with this syndrom , nancy klymas think WGV are different with ME/CFS patients , but WGI mens and womens are different in bio markers !! i have to wait at least 3 month to know if it will be good for us !
     
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  5. morse27

    morse27 Senior Member

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    i've received today an information from my scientist in USA who treat all ME/CFS in the world , with rituxan and other treatment, .....so, i 've not blood markers know in all patients with ME!! , i've have just SIBO test strongly positive than other sick ME people. but not common bio marker in blood test, he wrote me, i've and other auto immune illness in relation with the vaccine and squalene adjuvant, its a scoop for all veterans in USA , i'm the life prove than this illness is the result of the squalene vaccine , the same adjuvant in antrax vaccine for many soldiers used on first gulf war all hypothesis with pesticide , virgil or organosphosphate are faulse !!,thinking than a lot of vaccin can start this illness is not possible, just one vaccine running it on me, so i hope to contact a specialist in this illness , i'm going in USA in may ....if they understand than the trigger is the squalene i think this information done many way for research treatment , i know nancy klimas , but is there other scientist who search treatment for these soldiers ? did you know ?
     
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  6. Marco

    Marco Grrrrrrr!

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    Beatrice Golomb is more of a researcher than a clinician but focuses on oxidative stress/mitochondrial dysfunction :

    Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions:
    From Gulf War Illness to Autism Spectrum Disorder


    http://precedings.nature.com/documents/6847/version/1/files/npre20126847-1.pdf

    Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

    Eighty percent of treated veterans improved physical function

    https://health.ucsd.edu/news/releases/Pages/2014-11-03-CoQ10-helps-gulf-war-illness-symptoms.aspx
     
  7. morse27

    morse27 Senior Member

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    marco , its true with coenzyme Q10 but not sufficient to be able to work or make anything , improvment just 5 %
     
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  8. wdb

    wdb Senior Member

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    Am I missing something or of this a bit of a weak study. For a p value of <0.05 by pure chance alone you'd expect a false positive rate of 1 in 20 , so 5 out of 89 would not be inconsistent with chance alone.
     
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  9. morse27

    morse27 Senior Member

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    I give you my doctor wrote to the USA, which meets on my personal case, his experience on patients ME / CFS is strong in terms of biomarker analysis, if it says I have nothing common with the other patients, my concern is that since this vaccination are sound today, who else had this experience on ME / CFS I am disgusted to learn today, his email :

    Yvon you are asking excellent questions.
    I will try to answer simply and briefly. Your repeat NK was even higher and not at all consistent with our usual results in ME patients. Your ADH/vasopressin was normal. Your viral antibodies have not been very high.
    So, with the exception of your positive testing for SIBO, you do not fit the typical picture of our CFS/ME patients. I suspect you are correct and your illness results from the vaccine and adjuvant you received causing chronic inflammation and immune dysfunction. I do think that it is possible that the rituxan may still be helpful since the end result of the inflammation/immune dysfunction is NOT unlike what we see in our CFS patients.
    Hope this is helpful. I know it's all very frustrating.
     
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  10. morse27

    morse27 Senior Member

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    @picante , welcome to help me if my english is no perfect , thks
     
  11. picante

    picante Senior Member

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    @morse27 - Yvon, this chart was posted in another discussion recently by Kina.

     
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  12. picante

    picante Senior Member

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    Yvon's case is especially strange, since he was not in the Gulf War. He is a French civilian who had the H1N1 vaccine with the squalene adjuvant in 2009. That is why he says:

    [I'm the living proof that this illness is the result of the squalene-adjuvanted vaccine ... All hypotheses concerning pesticides, virgil, and organophosphates are false.]
    virgil? (Yvon, what is that? Vous pouvez me répondre par messagerie.)

    The really odd thing is that Yvon's diagnosis of Gulf War Syndrome was given by doctors at GlaxoSmithKline (the vaccine manufacturer!!), who examined him. Did they perform lab tests, Yvon?

    Also, did the doctors at the OMI in California give you any opinion on the GWS diagnosis? They say you don't fit the usual ME/CFS profile because of your NK cell count. But did they think that Gulf War Syndrome was accurate? Your doctor says this, at least:
     
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  13. morse27

    morse27 Senior Member

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    The safety monitoring service (pharmacovigilance) of GSK laboratory France, represented by Dr. Ema Karl, interviewed me for nearly an hour about the effects of the Pandemrix vaccine, and with no hesitation gave me the "Gulf War Syndrome" diagnosis. Actually, she told me that many such cases had been diagnosed worldwide in connection with this type of vaccine (Pandremrix or Arepanrix H1N1 with the AS03 squalene adjuvant, the same lipid molecule as the one used in the Novartis anthrax vaccine with the MF59 squalene adjuvant.

    You might wonder why there were more victims in the army than among the civilians who received H1N1. The reason is simple: the civilians received only one dose of squalene adjuvant, while the soldiers received 3 successive vaccines. The ones who had strong, reactive immune systems produced anti-squalene auto-antibodies.

    In response to my concerns that my lab tests were not giving the usual ME/CFS results, the doctor I'm seeing for Rituximab treatment told me that my blood test markers absolutely do not match those of his patients who respond to Rituximab. He said that my illness is indeed connected to this kind of vaccine, but that it is in no way comparable to ME.

    I'm disgusted that I began this difficult and costly treatment to no avail, and that the research will never get done on an illness that affects 300,000 people worldwide. However, I think that my experience should serve to confirm the cause of illness for the soldiers who took part in "Desert Storm" in 1991.

    thks "picante" for your help in good translation !
     
  14. nandixon

    nandixon Senior Member

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    I'm not sure, but there may be a misunderstanding here. When the OMI doctor says:

    He means that even though you probably don't have ME/CFS, the rituximab treatment might still work for you because the end result of your disease is like what is seen in his ME/CFS patients. ("Not unlike" means "like" - it's what is known as a "double negative.") So I think it's too soon to think that your treatment was to "no avail."

    @picante, when the OMI doctor says:

    I'm pretty sure "NK" is referring to natural killer cell function/activity, rather than count. I believe that low NK cell function and low vasopressin (ADH) are the two most common abnormalities the OMI finds in their ME/CFS patients.
     
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  15. picante

    picante Senior Member

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    I never thought to explain this, Nan! Good catch. Yvon, you could also say it's "not really different".

    I know absolutely nothing about this, but Yvon said in a private message that his is high:
    "CD16+CD56 à 26% high"
    And his doctor says "Your repeat NK was even higher and not at all consistent with our usual results in ME patients."

    Yvon, I agree that your doctor appears hopeful that the Rituximab will be effective because your SIBO, your inflammation and your immune dysfunction are things that Rituximab can often help. After all, it's a drug that's used for other illnesses, not just ME/CFS.
     
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  16. morse27

    morse27 Senior Member

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    i hope it can improve my illness, i continue this treatment , if it offer good result , a hope for this veterans of the first war gulf, and i see recently than squalene has been used in afganistan war for soldiers vaccines!! in fact many soldiers with PTSD are not psychological patients , but they have the same illness, the war gulf illness is classified in a new syndrom since 2010 : the ASIA syndrom by yehuda shoenfeld , auto immune syndrom induce by adjuvant , i have call this scientist a year ago to know how pake a diagnose, what sort of treatment is able for this patient......he says me : IVIG therapy is used for a long time with modest benefits. i explain him , this idea to use RITUXIMAB bio therapie for this illness , for him its a very stong treatment , dangerous.....no able for ASIA syndrom, yehuda shoenfeld is a scietist in auto immune disease in israel. i'll contact this scientist again, to inform him than rituxan give some little benefits after 6 years of illness .i saw than symptoms decreased in reverse order after 4 month , in see in all project in relation with WGI studies than RITUXIMAB is a clinical trial for veterans , but i dont know , where and when it will be start in USA .
    i think WGI need more infusion rituxan than ME to observe more benefits , i can compar my illness with a young woman of 32 years with severe ME , she had an adnormal pet scan with spinal cord and brain inflamation, she try now rituxan therapy . i can see many difference in his illness , she had zero ACTH brain hormon in blood and classic SPOT unable to stay up , in WGI its not common, the major difference is in gastrointestinal disorder , for mens impotence for all , i never heard in ME/CFS community the same problem for mens .the kina chart post by picante is clear , all this diseases have the same symptom, and i know other similar symptom disease : eg : neuro sarcoidosis, auto immune illness , thanks for your interest , yvon
     
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  17. picante

    picante Senior Member

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    Yvon has asked for any help I can provide with language, so here goes. He has been looking for input here on PR, but hasn't gotten much, as it's hard to read his posts:

     
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  18. picante

    picante Senior Member

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    Yvon, if I've misunderstood anything, be sure to correct it.
     
  19. morse27

    morse27 Senior Member

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    my friends american soldiers sent me a movie explain squalen scandale in all vaccines and the war gulf illness , exist too in 1998 / 1999 , and in 2009 with H1N1 flu vaccines , squalen is the most terrible adjuvant than scientist had made

    www.youtube.com/watch?v=wDDMsvErsQw
     
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