Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Elevated Energy Production in Chronic Fatigue Syndrome Patients

Discussion in 'Latest ME/CFS Research' started by A.B., Oct 18, 2016.

  1. wastwater

    wastwater Senior Member

    This hyper/hypo energy production study on corts site deserves its own thread
    Does it help explain PEM as well,if the energy production cycle is revved up just to put out minimal energy then when higher demand is placed on it,the demand cannot be met.
    As a side note FOXO genes are considered tumour surpressors
    TreePerson and Ritto like this.
  2. Hip

    Hip Senior Member

    It does, and this thread is it!
  3. Leopardtail

    Leopardtail Senior Member

    Great post Hip!!

    You have summarised my first resonse to the article (that these cells were out of the normal serum environment).

    I did not immediately consider metabolic blockings factors - though that is a good point well made.

    I did however consider the general metabolic support available in serum. Things like fuel availability (Glucose or Fatty Acids) levels of Vitamins, Minerals, Amino Acids, Catechols, Cortisol and Thryoid hormones. All of these things will affect cellular performance. The chemical baths used to grow these cells will more than likely have optimsed all relevant items and will not have reflected the situation in the patients own serum.
    trishrhymes and Hip like this.

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