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Effectiveness of high‐dose riboflavin in migraine prophylaxis.

Discussion in 'General Treatment' started by Ema, May 5, 2014.

  1. Ema

    Ema Senior Member

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    Seems cheap and easy enough to try...

    I'm especially intrigued by the hypothesis that migraine is also a result of mitochondrial dysfunction. That makes so much sense!

    http://www.neurology.org/content/50/2/466

    SDSue likes this.
  2. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    @Ema

    Aren't there some concerns with high dose riboflavin? Remembering the "I love B2 thread..."

    Sushi
  3. Ema

    Ema Senior Member

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    Oh, sure, point me towards the 40 page thread...LOL. I don't really remember much of that except it was contentious!

    From Linus Pauling Institute:

    http://lpi.oregonstate.edu/infocenter/vitamins/riboflavin/

    If someone knows of toxic effects, I'm happy to learn, though!
  4. SDSue

    SDSue Florida

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    You go first?

    It does look like it's worth a try. My doc wants to shoot me up with Botox, and I've resisted. My headaches definitely don't feel muscular. I describe them as an "inflamed brain", which gets me labeled as a whack job at the neurologist. But then, what doesn't get me labeled as a whack job at the neurologist? lol
  5. Ema

    Ema Senior Member

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    I did order some!

    But I ordered the activated version, R5P. I am really not sure how the doses compare to 400 mg of the "regular" riboflavin...

    I am poking around on the B2 thread...looks like Dogperson thought regular B2 was better (not sure why yet) though.

    I don't think migraines are muscular...vascular, maybe, but this mitochondrial theory makes so much sense to me. I see a few posts from richvank also that implicate riboflavin in the mitochondria which makes me even more interested in trying.
  6. SDSue

    SDSue Florida

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    My mito cocktail from Kendall contained the following:
    CoQ10 - 600 mg daily
    L-carnitine 1,000 mg daily
    Riboflavin 100 mg daily
    Alpha Lipoic Acid 600 mg daily

    I didn't notice much difference after taking for 9 months, other than my pocketbook started bitching about the $98/month. But then, nothing I have tried has made a lick of difference.

    So, there must be something to the Riboflavin. Interesting that the study used a much higher dose.

    Where did you order activated version?
  7. SDSue

    SDSue Florida

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    If I had to guess, the compounding pharmacy wasn't too worried about active forms. For example, the CoQ wasn't ubiquinol, so I'm not surprised I noticed no difference.
  8. Ema

    Ema Senior Member

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    I ordered the Thorne version from Amazon.

    I also ordered that "new" MitoQ. What can I say...I'm a sucker for new supplements.

    I was trying a mito cocktail of:

    MitoQ
    Taurine 1000mg
    ALC 1000mg
    Niagen, 125 mg

    3 times a day...but then my blood pressure tanked so I stopped it all. I think it might have been the taurine but I'll have to pick it apart to see if I can figure it out for sure.
  9. SDSue

    SDSue Florida

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    The PQQ? I'll be eager to hear how that works!

    I've about supplemented myself to death, to no avail. I'm growing weary and wary of any more. I'm circling back around thru my bins and re-trying things in different dosages, this time one at a time.

    I had considered taurine, as it apparently calms the sympathetic system even at doses of 1,000 per day? Maybe 3,000 was just to high? It definitely seems worth experimenting.[/quote]
  10. Ema

    Ema Senior Member

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    [/quote]
    No, I did try the PQQ last year though. I tried the blend with B6 and started having problems with my feet tingling and hurting...so I stopped it. I think there is one with PQQ alone though. Heck, I probably have it - I should check my closet! LOL.

    The MitoQ is this one:

    http://www.mitoq.com/supplements/

    I think there was another thread on it recently here...

    Everything about taurine sounded good to me...except the increased dizziness and fatigue. I did try taking just 1000 mg at bedtime but only for a couple of days before I decided I just needed to start over again more methodically.
  11. SDSue

    SDSue Florida

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    PubMed has many articles on mitoQ. Looks interesting in the lab, but unproven in clinical trials? I will be following this one, as it could have big ramifications.
  12. Ema

    Ema Senior Member

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    And the doses they used in the studies were FAR greater than what you get in a dose of MitoQ as well.

    But I was curious, so I bought it...
    SDSue likes this.

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