1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
ME/CFS and the Magic of the Canine Factor
There's been plenty of research indicating that having pets is good for your health. I never really noticed any particular benefits to having cats, though that may have had more to do with my cats. They've been fairly indifferent to my presence and we've shared a live-and-let-live...
Discuss the article on the Forums.

Eelevated neopterin - marker of immune system activation

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by nanonug, Apr 12, 2012.

  1. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    385
    Virginia, USA
    Today I received my urine test results for Metametrix Neopterin/Biopterin Profile. The results show an elevated level of neopterin. According to Wikipedia and neopterin.net, this is a marker for immune system activation. So, what is the bottom line? I now know for sure that my body is trying to "fight something". Next step is to determine what "something" is.
  2. adreno

    adreno 3% neanderthal

    Messages:
    2,319
    Likes:
    1,458
    Tundras of Europa
    Really? How do you know that? Isn't it possibly an autoimmune reaction; a dysregulated immune system?
  3. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    385
    Virginia, USA
    Yes, in that case "something" would be my own tissues.

    The job now is to identify the root cause. Once it is found, and hopefully corrected, neopterin levels should come down. Basically, while neopterin is high, I will continue to look for the problem. Once neopterin comes down, I will know that I not only found it but that it has been dealt with successfully.

    By the way, for those in the United States, Labcorp also offers serum and urine neopterin testing.
  4. adreno

    adreno 3% neanderthal

    Messages:
    2,319
    Likes:
    1,458
    Tundras of Europa
    If course, there is always the possibility that autoimmune disorders will turn out to be caused by pathogens. There are indications of this in some diseases already, but I believe it's too preliminary to draw any conclusions.

    How will you search for the root cause? Test for every pathogen known to man?
  5. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    385
    Virginia, USA
    Given my current gastrointestinal issues, I am now going to do the GI Effects Complete Profile test to see if something comes up. If nothing comes up, I will then schedule an appointment with an infectious specialist. I may end up asking for "empirical" treatment eventually. In this case, the idea is to try some antibiotics and/or some antivirals and see what happens.
  6. xks201

    xks201 Senior Member

    Messages:
    613
    Likes:
    184
    Have you tried any minerals like calcium or tested your saliva and urine PH? Just curious.
  7. nanonug

    nanonug Senior Member

    Messages:
    1,248
    Likes:
    385
    Virginia, USA
    Calcium is not so good for men but I did try it but doesn't do anything for me. Also, I never measured either saliva or urine pH. Any particular reason you ask?
  8. triffid113

    triffid113 Day of the Square Peg

    Messages:
    702
    Likes:
    223
    Michigan
    Oh. I just ordered taht biopterin test for my Dad since I have 3 genetic defects limiting biopterin ad he prolly does too...he's in dialysis now and not doing well. However the chances are good that although he is genetically low in biopterin, he may also have an infection going on -- it is very common in institutionalized elderly people (he is in rehab). I hope this test wont be a waste of time-?

See more popular forum discussions.

Share This Page