It usually took me a day to level out the potassium deficiencies with most of the correction done the first day and maybe adding what is need the next day . Mine is up to 2600mg so far and varies slightly from day to day. If it is low the next day I increase by 300mg until I can hold steady. Sometimes I can go several weeks without gut paralysis which is usually my first indicator of low potassium, spasms come later that day if I don't take an extra 300mg. I am on a prescription (Reglan, works great) for restarting my gut if needed. It has a black box warning and I dislike using it too often. I use less than a months worth a year, as little as possible. If used steadily it can cause permanent side effects, tardive dyskinesia.
I found that at 7.5mg or so that symptoms started disappearing and at 15 only 2 or 3 intermittent folate deficiency symptoms came up and at 30mg/day they are all gone and stay gone. Also at the higher folate doses my kidney problems are going away, no edema, mainly dealing with the liver damage from the antibiotic (Augmentin) which utterly clobbered me. One thing to remember, about mfolate doses; the Deplin to Quatrefolic (6S isomer) is 1:1.5 meaning 20mg of Deplin equals 30mg of 6S. They also have different absorbtion and body distribution from each other. I just recently started a trial with the 6S from MethylPro and will do a review soon. It is different is certain ways but I honestly can't say if that is better or only different. Also the dose taken at one time may effect tissue penetration with higher doses at one time having a different profile form more smaller doses.
I am presently doing high dose MeCbl (3x10mg injected) because I have trouble getting it into my brain, 45mg of 6S in 3x15mg doses (equivalent to 3x10mg of Deplin) dose wise and 2600mg of potassium. I have no folate deficiency symptoms variations from day to day. I'm on the edge of enough potassium. Don't forget B1, B2 and B3 can increase both needed doses of potassium and mfolate and increase symptoms instead of decreasing them.
I found that increasing the methylfolate by 50% a day was effective for a fast titration to zero folate symptoms. Then if they come back again another such dose. However, if each single dose wasn't reducing the symptoms within a couple of hours, each dose needed increasing by 50% until each dose has an effect. Then one can work on merging the effect into a continual lessening until all folate symptoms are gone and stay gone. Progress was fast after 7.5mg daily dose. Increasing the folate can cause an increase in potassium too but it is not linear. Each doubling of folate might cause only a few hundred mgs of additional potassium.
In reading up across the internet, those taking it to 30mg are having outstanding results. And I don't know if it is that some of us just have bad absorption or, like me low cellular folate for genetic reasons.
