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9th Invest in ME International ME Conference, 2014 - Part 1: Autoimmunity and ME
Mark Berry begins a series of articles on the 9th Invest in ME International ME Conference in London, with a look at three presentations on autoimmunity
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  1. Fuzzyhead

    Fuzzyhead Senior Member

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    I had bloods done and the EBV IgG was reactive which means evidence of past EBV infection more than 8 weeks ago, the autoantibody screen showed positive nuclear antibody with homogenous HEp2 pattern. Does anyone know what all this means?
     
  2. golden

    golden Senior Member

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    Hi,

    I am not sure it means very much. I tested positive for EBV (more than 8 weeks ago) i actually had a bad case of it where my throat swelled to the size of a tree trunk when I was younger and followed problems.

    But I think lots of people upto 90%? may test positive for it?

    Not totally sure. Will be interested to hear the answer from an expert myself...

    Peace
     
  3. Ema

    Ema Senior Member

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    Usually, a chronic EBV panel will include the following:



    Test results most likely indicate the following (from http://labtestsonline.org/understanding/analytes/ebv/tab/test):

    VCA-IgM VCA-IgG EA-D, IgG EBNA, IgG Possible Interpretation
    Negative Negative Negative Negative No infection, symptoms due to another cause, susceptible to EBV infection
    Positive Positive Negative Negative Early, primary infection
    Negative or positive Positive Positive Negative Active infection, though EA-D IgG may persist for life in about 20% of people
    Negative Positive Negative Positive Past infection
    Negative Positive Positive Positive May indicate reactivation of virus

    So there is more to the picture than just one positive IgG level. I would find out what test you had done and get the others to see if they are positive as well. If they are very strongly positive, some people also thinks that indicates a greater chance of a reactivated infection.

    The ANA screen is totally separate and is used to help confirm a diagnosis of autoimmune disease. It can be false positive in 13% of cases according to this article though so it is just a jumping off point and may or may not be meaningful.

    http://www.sciencedaily.com/releases/2011/01/110104071651.htm

    A homogenous pattern may be associated with lupus or connective tissue disorder so these need to be ruled in/out.

    https://labtestsonline.org/understanding/analytes/ana/tab/test

    Here are some common follow up tests to a positive ANA:


    "In people with a positive ANA, more tests are usually performed to check for other antibodies that can help to confirm the diagnosis. Certain autoantibodies and substances in the blood can give information about which autoimmune disease, if any, is present. To check for these antibodies, doctors usually order what is called an ANA panel, which checks for the following antibodies: anti-double-stranded DNA, anti-Smith, anti-U1RNP, anti-Ro/SSA, and anti-La/SSB. Some laboratories also include other antibodies in their panel, including antinucleoprotein, anticentromere, or antihistone."

    http://www.hopkinslupus.org/lupus-tests/lupus-blood-tests/

    But they both give you a good place to start to follow up. Hopefully your doctor has ordered more testing?



    Ema
     

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