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EBV peptide test

Discussion in 'Latest ME/CFS Research' started by Joolz, Jul 22, 2015.

  1. Joolz

    Joolz

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    Little Bluestem and Billt like this.
  2. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    Do you know if it would work in a person who has been ill for decades?
     
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  3. maryb

    maryb iherb code TAK122

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    I'd like to know that too.
     
  4. Hip

    Hip Senior Member

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    Would you know how this is actually used as a diagnostic test? It seems to be a set of antigens from the Epstein-Barr virus, designed to stimulate an anti-EBV immune response.
     
  5. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I don't think this is going to be a diagnostic test of any sort. It may be a way of stratifying patients by their T cell responses to different peptides from EBV but I don't think that will say anything about whether or not the EBV has anything to do with their ME. I guess it would be more likely to reflect their MHC genetics.
     
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  6. Joolz

    Joolz

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    I heard from one of prof Scheibenbogen's patients that the test is supposed to be used for diagnosing an EBV-specific fatigue, regardless of PCR results. She seems to think that [a subset of?] CFS patients suffer from repeated EBV replications (complete or incomplete). I'm just quoting, I haven't talked to her for almost a year, but she mentioned the test to me back then as well.

    I have no idea, but my guess would be yes. Why? Because the test has been developed in the context of the 2014 paper on EBV/CFS (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085387) where the average disease duration is around 7 years with a range up to the 30s.

    Prof. Scheibenbogen will also perform a (treatment) study on 10 CFS (probably EBV-triggered, as this is their main research focus?) patients from autumn 2015. It shouldn't take too long before results are published, if I understood correctly.
     
    RL_sparky and Hip like this.
  7. Hip

    Hip Senior Member

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    Interesting paper. They say that they found deficient memory B-cell and T-cell response in ME/CFS patients, suggesting an impaired ability to control early stages of EBV reactivation.


    I wonder if this links up to a previous 2012 study (from Lerner et al) which found partial EBV reactivation in some ME/CFS patients generating two viral proteins, DNA polymerase and dUTPase, with the patients producing antibodies to neutralize these proteins (actual paper here).
     

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