Phoenix Rising: The Gift That Keeps on Giving All Year Long
This holiday season Jody Smith turns her eyes to the people of Phoenix Rising and gives thanks for you all ...
Discuss the article on the Forums.

E.Coli and Serotonin

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by outdamnspot, Feb 17, 2017.

  1. outdamnspot

    outdamnspot Senior Member

    Messages:
    392
    Likes:
    109
    According to this article, Mutaflor increases Serotonin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663480/

    I've been taking Symbioflor 2 for a week now. Initially, I thought the mood symptoms (agitation, spaciness, derealization etc.) were due to a herx, but I'm starting to wonder if they may be due to serotonin modulation.

    Is that plausible, and if so, should I stick it out? I never did well on SSRIs etc. though they typically made me numb, whereas since starting the Symbioflor, my mood is far more labile and I want to cry all the time.
     
    MEMum likes this.
  2. outdamnspot

    outdamnspot Senior Member

    Messages:
    392
    Likes:
    109
    Alternatively, I wonder if it could be due to effects on methylation? Doesn't Mutaflor jumpstart methylation? I think I recall reading that. Methylfolate made me horribly depressed.
     
  3. Crux

    Crux Senior Member

    Messages:
    1,094
    Likes:
    750
    USA
    I remember crying for hours at a time when I took SSRIs.
     
  4. Basilico

    Basilico Florida

    Messages:
    700
    Likes:
    1,574
    It's definitely possible the probiotics could be introducing some changes in the neurotransmitter balance. I actually just linked a very interesting article on another thread, but it relates directly to what you are experiencing: https://www.scientificamerican.com/article/gut-second-brain/

    Are you taking other supplements that could have effects on neurotransmitters or MAO enzymes? (Like turmeric, for example, is a weak MAO inhibitor, or St. John's Wort, or amino acids like tryptophan or 5HTP, etc...). If yes, then you might want to suspend taking those things and stick with the SymbioFlor2 for the time being.

    I am very skeptical about the concept of a herxheimer reaction, because there is only scientific proof that it happens with a very few specific pathogens (such as Syphilus and Lyme) and I really think that this whole idea that everything can cause a herxheimer reaction is just a way for "CFS specialists" who don't really know what's going on try to find an explanation for what's happening with their patients. I believe that what CFS patients often experience is not a herx reaction, but a hypersensitivity. There are so many people who are told they are having a herx reaction and to stick with a treatment, and continuation of the treatment ends up causing serious harm (my husband had this experience with SIBO antibiotics).

    If you aren't taking anything else that could be causing this mood reaction and you continue to experience this, then my advice would be to suspend the SymbioFlor2.
     
    JES and TigerLilea like this.
  5. outdamnspot

    outdamnspot Senior Member

    Messages:
    392
    Likes:
    109
    @Basilico Thank you for your reply. I'm not taking any other supplements and actually suspended the SymbioFlor2 a week ago, though according to Ken, E.Coli probiotics can persist for up to 20 weeks in the gut.

    I feel a bit torn. Before I started the SymbioFlor2, I was so weak I could barely move. Within a few days, it robustly improved my 'adrenal' function, i.e. needed a lot less salt, had more mental energy, normal sexual function, didn't feel like I was dying. But the spaciness/aggression/fits of teariness etc. were too much. I felt good mentally for the first week (almost euphoric), so I wonder if maybe my serotonin receptors are overly sensitive and it was agonizing them .. and they would eventually downregulate. Going day-after-day in that state was difficult. But I've stopped it and am back to the weak/dying-feeling. So not sure which is worse :(
     

See more popular forum discussions.

Share This Page