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Dysbiosis Treatment with ABX, KDM

Aubry

Senior Member
Messages
189
I reached small remission in 2015 during oral Clindamycin pulsed for gut dysbiosis/sibo. Very hard to achieve this result nowadays but I keep hoping.
 

Aubry

Senior Member
Messages
189
KDM said for now this is all he can do :/ Because there is some mechanism broken (JAK1 pathway) so inflammation of gut don't stop. Only thing he can do is try to modulate the small and large intestines with herbs or antibiotics + probiotics (reduce overgrowth) in order to have a proper immune respons and no chronic immune activation which makes us ill. In 2019 the JAK1 inhibitor will be available on the market and then we all can cure he said. It keeps raining and all we can do is keep pumping the water away...
 

Banana94

Senior Member
Messages
160
Location
Denmark
KDM said for now this is all he can do :/ Because there is some mechanism broken (JAK1 pathway) so inflammation of gut don't stop. Only thing he can do is try to modulate the small and large intestines with herbs or antibiotics + probiotics (reduce overgrowth) in order to have a proper immune respons and no chronic immune activation which makes us ill. In 2019 the JAK1 inhibitor will be available on the market and then we all can cure he said. It keeps raining and all we can do is keep pumping the water away...

Are you on a low carb diet aubry? This can also reduce unflammation in the gut..
 

bertiedog

Senior Member
Messages
1,738
Location
South East England, UK
Has anyone ever mentioned the role of serotonin in the gut? My migraine specialist mentioned it to me today saying that what I thought might be leaky gut symptoms during a severe migraine attack he thought it far more likely to be the role that serotonin plays in a migraine as it is also produced in the gut and can disrupt its function?

Just a thought I was having.

Pam
 

Daffodil

Senior Member
Messages
5,875
Has anyone ever mentioned the role of serotonin in the gut? My migraine specialist mentioned it to me today saying that what I thought might be leaky gut symptoms during a severe migraine attack he thought it far more likely to be the role that serotonin plays in a migraine as it is also produced in the gut and can disrupt its function?

Just a thought I was having.

Pam
KDM says we aren't making serotonin ( or maybe much of it?). I forget the pathway that is involved.....
 

JES

Senior Member
Messages
1,320
KDM said for now this is all he can do :/ Because there is some mechanism broken (JAK1 pathway) so inflammation of gut don't stop. Only thing he can do is try to modulate the small and large intestines with herbs or antibiotics + probiotics (reduce overgrowth) in order to have a proper immune respons and no chronic immune activation which makes us ill. In 2019 the JAK1 inhibitor will be available on the market and then we all can cure he said. It keeps raining and all we can do is keep pumping the water away...

I wonder if this JAK1 inhibitor is the "new discovery" that KDM was talking about last spring according two independent sources here and here. The announcement from him was supposed to be due July 2017, but yet nothing.
 

JaimeS

Senior Member
Messages
3,408
Location
Silicon Valley, CA
KDM says we aren't making serotonin ( or maybe much of it?). I forget the pathway that is involved.....

I went into studying serotonin early on, because I had such drastic responses to serotinergic precursors like 5-HTP.

1) The serotonin in the general bloodstream has zero to do with the serotonin behind the blood-brain barrier.
2) Your serotonin may be low, but if your receptors have increased sensitivity, then it may not be something you need to increase.
3) Patients may have serotonin autoantibodies, which makes increasing serotonin problematic (one study found 2/3 of patients in a decent-sized cohort had autoantibodies to serotonin).
4) Check your SNPs. If you break down serotonin slowly, low may be more normal for you.
 

Banana94

Senior Member
Messages
160
Location
Denmark
I wonder if this JAK1 inhibitor is the "new discovery" that KDM was talking about last spring according two independent sources here and here. The announcement from him was supposed to be due July 2017, but yet nothing.

Dont wanna talk bad about KDM. He's a good doctor. But it seems like he often announced that he found the reason of me/cfs. He also doesnt care about low carb diets and methylation support (except hydroxoB12) which has helped many PWME.
Would really appreciate if he found the reason and has a treatment.
 

unicorn7

Senior Member
Messages
180
Dont wanna talk bad about KDM. He's a good doctor. But it seems like he often announced that he found the reason of me/cfs. He also doesnt care about low carb diets and methylation support (except hydroxoB12) which has helped many PWME.
Would really appreciate if he found the reason and has a treatment.

I read in an interview with a SIBO-researcher that they don't recommend going completely low carb when you're taking antibiotics for SIBO. Because most of the antibiotics work on the mechanism of disrupting growth and replication in bacteria, it's better to feed the bacteria when you're trying to kill them. Happy bacteria are apparently easier to kill.

I tried low carb, didn't work for me. It was pretty hard to do with my food intolerances for egg, soy, casein and several nuts.
 

Aubry

Senior Member
Messages
189
I see the JAK inhibitor doesn't have influence on IL-8 apparently.... Which is often elevated in ME/CFS/ ... Lyme ... and defined mostly as herxing
 

dadouv47

Senior Member
Messages
745
Location
Belgium
I read in an interview with a SIBO-researcher that they don't recommend going completely low carb when you're taking antibiotics for SIBO. Because most of the antibiotics work on the mechanism of disrupting growth and replication in bacteria, it's better to feed the bacteria when you're trying to kill them. Happy bacteria are apparently easier to kill.

I tried low carb, didn't work for me. It was pretty hard to do with my food intolerances for egg, soy, casein and several nuts.

Interesting. Do you have a link? Thanks!
 
Messages
1
Chris kresser and mark pimental or pimentel advocate prebiotics with sibo treatment. Otherwise the bacteria go into survival mode, they can go without food for a very long time.

So you get them to come out to eat, guar gum Kresser uses, then zap them with the antimicrobials. I assume antibiotics would be the same.

It's an easy Google search.
 

Banana94

Senior Member
Messages
160
Location
Denmark
Update:

After 2 months of Azithromycin and 3 moths of Xifaxan (15d/month) my Bacteroides went from 30% to 46%!!
So in my opinion KDM's treatment completely failed.
All he said was: We try Azithromycin.
I insisted that I already had this, and gives me bad diarreha..
Than he told me he will think aboute it and will prescribes me some other ABX.
I don't no which one. It's hard to get a word out of his mouth!
Does anybody has the same experiences with bactericides overgrowth? Is there another treatment like diet?
I don't no if I should take any ABX fore the gut, it doesn't seem to be very successful? Other experiences?
 

Aubry

Senior Member
Messages
189
You should get metronidazole, ornidazole, tinidazole antibiotic class to address this high bacteroides