Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Dysbiosis Treatment with ABX, KDM

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by Banana94, Aug 20, 2017.

  1. Aubry

    Aubry Senior Member

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    I reached small remission in 2015 during oral Clindamycin pulsed for gut dysbiosis/sibo. Very hard to achieve this result nowadays but I keep hoping.
     
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  2. Aubry

    Aubry Senior Member

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    KDM said for now this is all he can do :/ Because there is some mechanism broken (JAK1 pathway) so inflammation of gut don't stop. Only thing he can do is try to modulate the small and large intestines with herbs or antibiotics + probiotics (reduce overgrowth) in order to have a proper immune respons and no chronic immune activation which makes us ill. In 2019 the JAK1 inhibitor will be available on the market and then we all can cure he said. It keeps raining and all we can do is keep pumping the water away...
     
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  3. Daffodil

    Daffodil Senior Member

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    :::doing a dance, waiting for 2019::::
     
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  4. Banana94

    Banana94 Senior Member

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    Are you on a low carb diet aubry? This can also reduce unflammation in the gut..
     
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  5. bertiedog

    bertiedog Senior Member

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    Has anyone ever mentioned the role of serotonin in the gut? My migraine specialist mentioned it to me today saying that what I thought might be leaky gut symptoms during a severe migraine attack he thought it far more likely to be the role that serotonin plays in a migraine as it is also produced in the gut and can disrupt its function?

    Just a thought I was having.

    Pam
     
  6. Helen

    Helen Senior Member

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    KDM did. I´m lucky not to have symptoms related to low serotonin, but I know from other patients of KDM that he is well aware of this connection and takes it into consideration as of his protocols.
     
    Last edited: Sep 4, 2017
  7. Daffodil

    Daffodil Senior Member

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    KDM says we aren't making serotonin ( or maybe much of it?). I forget the pathway that is involved.....
     
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  8. JES

    JES Senior Member

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    I wonder if this JAK1 inhibitor is the "new discovery" that KDM was talking about last spring according two independent sources here and here. The announcement from him was supposed to be due July 2017, but yet nothing.
     
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  9. aquariusgirl

    aquariusgirl Senior Member

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    snowathlete... have you checked to see if you have the FUT2 genes? associated with UC IIRC.......
     
  10. JaimeS

    JaimeS Senior Member

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    I went into studying serotonin early on, because I had such drastic responses to serotinergic precursors like 5-HTP.

    1) The serotonin in the general bloodstream has zero to do with the serotonin behind the blood-brain barrier.
    2) Your serotonin may be low, but if your receptors have increased sensitivity, then it may not be something you need to increase.
    3) Patients may have serotonin autoantibodies, which makes increasing serotonin problematic (one study found 2/3 of patients in a decent-sized cohort had autoantibodies to serotonin).
    4) Check your SNPs. If you break down serotonin slowly, low may be more normal for you.
     
  11. Banana94

    Banana94 Senior Member

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    Dont wanna talk bad about KDM. He's a good doctor. But it seems like he often announced that he found the reason of me/cfs. He also doesnt care about low carb diets and methylation support (except hydroxoB12) which has helped many PWME.
    Would really appreciate if he found the reason and has a treatment.
     
  12. Jesse2233

    Jesse2233 Senior Member

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    This seems like something that deserves it's own thread. Wonder if KDM is referring to Ruxolitinib
     
  13. Marc_NL

    Marc_NL Senior Member

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    He refers to Filgotinib:
    http://www.glpg.com/clinical-pipelines


    .
     
    Last edited: Sep 9, 2017
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  14. unicorn7

    unicorn7

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    I read in an interview with a SIBO-researcher that they don't recommend going completely low carb when you're taking antibiotics for SIBO. Because most of the antibiotics work on the mechanism of disrupting growth and replication in bacteria, it's better to feed the bacteria when you're trying to kill them. Happy bacteria are apparently easier to kill.

    I tried low carb, didn't work for me. It was pretty hard to do with my food intolerances for egg, soy, casein and several nuts.
     
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  15. Aubry

    Aubry Senior Member

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  16. Aubry

    Aubry Senior Member

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    I see the JAK inhibitor doesn't have influence on IL-8 apparently.... Which is often elevated in ME/CFS/ ... Lyme ... and defined mostly as herxing
     
  17. dadouv47

    dadouv47 Senior Member

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    Interesting. Do you have a link? Thanks!
     
  18. Amazedby23andme

    Amazedby23andme

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    Chris kresser and mark pimental or pimentel advocate prebiotics with sibo treatment. Otherwise the bacteria go into survival mode, they can go without food for a very long time.

    So you get them to come out to eat, guar gum Kresser uses, then zap them with the antimicrobials. I assume antibiotics would be the same.

    It's an easy Google search.
     
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  19. Banana94

    Banana94 Senior Member

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    Update:

    After 2 months of Azithromycin and 3 moths of Xifaxan (15d/month) my Bacteroides went from 30% to 46%!!
    So in my opinion KDM's treatment completely failed.
    All he said was: We try Azithromycin.
    I insisted that I already had this, and gives me bad diarreha..
    Than he told me he will think aboute it and will prescribes me some other ABX.
    I don't no which one. It's hard to get a word out of his mouth!
    Does anybody has the same experiences with bactericides overgrowth? Is there another treatment like diet?
    I don't no if I should take any ABX fore the gut, it doesn't seem to be very successful? Other experiences?
     
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  20. Aubry

    Aubry Senior Member

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    You should get metronidazole, ornidazole, tinidazole antibiotic class to address this high bacteroides
     
    Banana94 likes this.

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