Hello dear reader! First of all: sorry if I'm asking the patently obvious, or the thing that has already been dealt with endlessly. Please know that I have been Googling for days and searching this site, but right now I simply can't see the wood for the trees anymore. Sniff. I'm spinning. As English is not my mother tongue and as I have difficulty understanding and concentrating (due to bad health), I'm hoping somebody will be able to help me to get me on the right track, to help me to some clear answers. First let me introduce myself: I'm a Dutch woman, with health problems for over twenty years. To name a few: fatigue, aphasia, ataxia, tingling sensations in arms and legs, muscles ache. ME/CFS. Feb 2012: B12 deficiency. (B12: 119). August 2012: Dientamoeba fragilis. Unclear gut probs: biliary colic or infection. November 2012: MTHFR C677T, heterozygous. Now. I started with hydroxob12 injections in February, they were doing me some good, but ever since my gut problems in August things have been deteriorating. Fatigue is worse, nowadays even putting a jeans or some socks on makes me short of breath. Tingling is back. I'm bumping into more things than having experienced for a while. Etc. Standard procedure in The Netherlands is to treat B12 deficiency with hydroxoB12 injections. I've read on a Dutch forum that some people had gotten some improvements when injecting themselves with methylB12 alternating with either hydroxoB12 or adenoB12. MethylB12 and adenoB12 have to be ordered abroad though, they are not registered in my country. Because I am experiencing deterioration, I thought: maybe I should try methylB12 and adenoB12 myself. So I started to search the internet for more information - phew, wow - and all of a sudden I find myself in a swamp of medical technical discussions about things I'd never heard of before. Methylation for one. Some lab outcomes, September 2012: K (potassium): 4.3 nmol/l Calcium: 2.48 nmol/l Ferritine: 99 ug/l Vit D (25OH-D3): 85 nmol/l Folium acid: 41.5 nmol/l I am/have been using: - Vitamine D: 20mcg a day, taken with oil. - Injections: 1 mg Hydroxob12 twice a week. - Orthica Co-enzym B-complex: 1 tablet twice a week, taken with food. (Ingredients: B1: 5 mg, B2 (riboflavin-5-phosphate): 5 mg, niacin (inositol hexanicotinate): 50 mg, B5: pantothenic acid (calcium-D-pantothenate): 50 mg, B6 (pyridoxal-5-phosphate): 5 mg, calcium methylfolate (Metafolin®): 200 mcg, B12 (adenosylcobalamine): 25 mcg, biotin: 12 mcg, choline bitartrate: 50 mg, inositol: 50 mg, PABA (para-aminobenzoic acid): 15 mg) - Clioquinol (against Dientamoeba fr.): 2 treatments of 10 days each. - Started with oregano oil in November: ADP Biotics in order to kill the Dientamoeba and any other un/wanted minions in my body (duration: 6 weeks in total: two weeks 4 tablets a day, 2 weeks off, and again 2 weeks 4 tablets a day - coming Monday will be my last day) I was planning to use: - Orthiflor plus - probiotics - Orthica L-glutamine 500. - Injections: 1mg methylB12 and 1 mg adenoB12 (each once a week) Okay, please bear with me, here are some (stupid?) questions: 1. Is it possible hydroxoB12 is not working for me because I'm having a genetic mutation (C677T)? 2. What's the effect of C677T on being under- or overmethylated? 3. How do I notice under- or overmethylation? (Perhaps someone has a link?) 4. Is it wise for me to take the methylB12 and adenoB12 injections or would 'sublingual' tablets work just as fine for me? Or should I use both: injections AND tablets? If so: any idea how much? 5. Oregano oil is a natural antibiotic, so I've learned, and is known to give problems with iron absorption. Is it possible to have an an iron shortage after using oregano oil for two weeks? 6. Should I go ahead with the probiotics (Orthica: Orthiflor plus)? 7. Is Orthica L-glutamine 500 okay for me? 8. Are there any other supplements I should be taking? Thanks for your patience, thanks for reading, thanks for any answers. Edit, addition, after giving my mind one hour of peace: Maybe, probably, 8 questions is too much, but maybe, dear reader, you could answer this one question, which was coincidentally already in the header: what do you think would be the best approach for me? Thanks!